高锰酸钾退色光度法测定阿昔洛韦  

Spectrophotometric determination of acyclovir by decoloration of potassium permanganate

作　　者：刘英红[1] 吉丹[1] 马卫兴[1] 周丽华[1] 

机构地区：[1]淮海工学院化学工程学院,江苏连云港222005

出　　处：《化学试剂》2010年第5期434-436,共3页Chemical Reagents

基　　金：江苏省高校自然科学研究计划课题资助项目(05KJB15003);淮海工学院自然科学校内课题资助项目(Z2008025)

摘　　要：在稀硫酸介质中,阿昔洛韦与高锰酸钾发生氧化还原反应,溶液退色,辛基苯基聚氧乙烯醚(OP乳化剂)对反应有增敏作用,最大退色波长为525nm。退色程度和阿昔洛韦的浓度成正比,据此建立了测定阿昔洛韦含量的光度法。在最大吸收波长处,阿昔洛韦浓度在0～18μg/mL范围内符合比尔定律,检出限为1.6μg/mL。方法用于尿液和药物制剂中阿昔洛韦含量的测定,结果满意。In dilute sulfuric acid medium,the color of KMnO4 solution can be faded by acyclovir reduction in the presence of OP as sensitivity agent with a maximum absorption wavelength occurring at 525 nm.The degree of color fading was proportional to the concentration of acyclovir.Based on the above results,a new spectrophotometric method for the determination of acyclovir was proposed.The concentration of acyclovir in the range of 32.1～244.7 μg/mL obeyed the Beer＇s law and the detection 1imit of the method was 1.6 μg/mL.The method has been used in the determination of acyclovir in medicine samples and human urine with satisfactory results.

关 键 词：高锰酸钾 阿昔洛韦 退色光度法 

分 类 号：O657.32[理学—分析化学]