N^2,N^2,N^6,N^6-四乙基-4-醛基吡啶-2,6-二甲酰胺的合成  

Synthesis of N^2,N^2,N^6,N^6-tetraethyl-4-formylpyridine-2,6-dicarboxamide

作　　者：时光好[1] 陶晓明[1] 肖海波[1] 王磊[1] 陈敏娟[1] 

机构地区：[1]上海师范大学化学系,上海200234

出　　处：《化学试剂》2010年第5期458-460,共3页Chemical Reagents

基　　金：上海师范大学科研资助项目(SK200839);上海市教委科研创新项目(09YZ160)

摘　　要：以2,6-二甲基吡啶为原料,经KMnO4氧化、二乙胺酰胺化、吡啶环自由基亲核取代反应得到N2,N2,N6,N6-四乙基-4-羟甲基吡啶-2,6-二甲酰胺,然后用Sarret试剂氧化得到标题化合物并探讨了氧化反应的最佳条件,产物结构经1HNMR、IR和MS得到表征。该产物是合成新型吡啶类有机配体的重要中间体。N^2,N^2,N^6,N^6-Tetraethyl-4-hydroxymethylpyridine-2,6-dicarboxamide was synthesized using 2,6-dimethylpyridine as the starting material via oxidation with KMnO4,amidation and free-radical substitution on pyridine ring.The final product was obtained by oxidation of N2,N2,N6,N6-tetraethyl-4-hydroxymethylpyridine-2,6-dicarboxamide with the Sarret reagent and the factors influencing the reaction were discussed.The structure of target product was characterized by 1HNMR,IR and MS.The target product is an important organic intermediate for the synthesis of novel ligands containing pyridine-2,6-dicarboxylic acid.

关 键 词：吡啶-2 6-二甲酸 氧化 合成 

分 类 号：O627.41[理学—有机化学]