大麻素系统抗动脉粥样硬化作用的研究进展  

Endocannabinoids and Cannabinoid Receptors in Atherosclerosis

作　　者：赵艳[1] 袁祖贻[1] 

机构地区：[1]西安交通大学第一附属医院心血管内科,陕西西安710061

出　　处：《心血管病学进展》2010年第3期449-451,共3页Advances in Cardiovascular Diseases

摘　　要：大麻素系统包括内源性大麻素;大麻素受体;降解大麻素的酶。研究显示大麻素与动脉粥样硬化关系密切。主要体现为:大麻素受体1与摄食,肥胖,胰岛素抵抗有密切关系,大麻素受体2与调节免疫,抑制炎症关系密切;大麻素降解酶可抑制体内的炎症物质产生,改善与年龄相关的心脏功能降低。以上这些都具有潜在的抗动脉粥样硬化作用。因此,深入探讨大麻素系统在动脉粥样硬化过程的作用对阐明动脉粥样硬化发生机制,开发抗动脉粥样硬化药物有重要意义。Cannabinoid receptors,endocannabinoids and a set of endocannabinoid-synthesizing and degrading enzymes constitute the endocannabinoid system.A growing body of evidence suggests that cannabinoid signaling plays a fundamental role in atherosclerosis development and its clinical manifestations.The possible mechanisms of endocannabinoid system suppressing atherosclerosis include： cannabinoid receptor 1 which is mainly expressed in the central nervous system and contributes to food intake,modulation of blood pressure and heart rate,improvement of serum lipid and insulin resistance;cannabinoid receptor 2 is expressed mainly in immune cells and is thought to play an important part in the immunosuppressive and anti-inflammatory effects of cannabis and cannabinoids;Endocannabinoid anandamide metabolizing enzyme,the fatty acid amide hydrolase,is emerging as a promising novel approach for the treatment of various inflammatory disorders.Pharmacological inhibition of the fatty acid amide hydrolase may represent a novel protective strategy against chronic inflammation,oxidative/nitrative stress,and apoptosis associated with cardiovascular aging and atherosclerosis.These findings may open novel therapeutic avenues upon clarifying the pathophysiolgy of atherosclerosis and development of new anti-atherosclerosis drugs.This review summarizes the latest advances on the recently identified role of cannabinoid receptors 2 in the pathophysiology of atherosclerosis.

关 键 词：大麻素 动脉粥样硬化 胰岛素抵抗 炎症 

分 类 号：R285.5[医药卫生—中药学]