具有细胞毒性的两种四羟基甾醇化合物的分离与结构  

Isolation and Identification of Two Tetrahydroxylated Sterols with Cytotoxic Activity

作　　者：廖小建[1] 徐石海[1] 林慧[1] 

机构地区：[1]暨南大学化学系,广州510632

出　　处：《有机化学》2010年第5期749-752,共4页Chinese Journal of Organic Chemistry

基　　金：国家863计划(No2006AA09Z408);国家自然科学基金(No20772048)资助项目

摘　　要：报道南海湛江硇洲岛软珊瑚Dendronephthya sp.中两种具有细胞毒性的四羟基甾醇化合物:23-降-24-亚甲基-麦角甾-3β,5α,6β,7β-四醇(1)和24-亚甲基-麦角甾-3β,6β,9α,19β-四醇(2),其结构通过波谱和化学方法确定,其中化合物1为新化合物,化合物2首次从该属珊瑚中获得.化合物1对肿瘤细胞BEL-7402,MCG,MCF,LOVO和HepG-2具有抑制作用,其IC50值分别为32.2,20.5,2.0,5.5和18.6μg/mL;化合物2对肿瘤细胞MCG和LOVO作用的IC50值分别为22.0和和13.8μg/mL.Two cytotoxic activity sterols 23-nor-ergost-24（28）-ene-3β,5α,6β,7β-tetrol （1） and ergost-24（28）-ene-3β,6β,9α,19β-tetrol （2） from Dendronephthya sp. collected from Naozhou Islands of the South China Sea have been reported. Their structures were defined by spectroscopic and chemical methods. Sterol 1 is a new compound, which exhibited cytotoxicity against BEL-7402, MCG, MCF, LOVO and HepG-2 cells （IC50 32.2, 20.5, 2.0, 5.5 and 18.6 μg/mL, respectively）. Sterol 2 also showed significant cytotoxicity against MCG and LOVO cells （IC50 22.0 and 13.8 μg/mL, respectively）.

关 键 词：软珊瑚 Dendronephthya SP 多羟基甾醇 细胞毒活性 

分 类 号：R284[医药卫生—中药学]