新的氨基甲酸酯型猪去氧胆酸分子裂缝的设计与微波合成  

Design and Synthesis of Novel Carbamate-Type Molecular Clefts Derived from Hyodeoxycholic Acid under Microwave Irradiation

作　　者：陈宇[1] 赵志刚[1] 王晓庆[1] 刘兴利[1] 易奉敏[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041

出　　处：《有机化学》2010年第5期768-772,共5页Chinese Journal of Organic Chemistry

基　　金：国家民委自然科学基金(No09XN08)资助项目

摘　　要：在微波辐射条件下,以α-猪去氧胆酸甲酯为隔离基,通过氨基甲酸酯键挂接芳胺手臂到3α位上,设计合成了10个新的氨基甲酸酯型猪去氧胆酸分子裂缝.其结构均经1HNMR,IR,MS及元素分析所确证,并且考察了这类受体对D/L-氨基酸甲酯的识别性能.初步研究表明,这类分子裂缝对所考察的客体有良好对映选择性识别能力.Ten new molecular clefts were designed and synthesized in good yields by using nyooeoxycholic acid as spacer and different aromatic amines as arms attached at 3α-position of hyodeoxyeholic acid via triphosgene under microwave irradiation. Their structures were characterized by ^1H NMR, IR, MS techniques and elemental analysis. The recognition properties of these molecular clefts for D/L-amino acid methyl esters were investigated. The preliminary results indicate that these molecular clefts have good enantioselectivity for D/L-amino acid methyl esters.

关 键 词：猪去氧胆酸 微波辐射 合成 分子裂缝 

分 类 号：TQ460.1[化学工程—制药化工]