尾部悬吊大鼠不同部位动脉血管的分化性结构重塑变化及其可逆性  

Differentiated Remodeling Changes of Medium sized Arteries from Different Body Parts in Tail suspended Rats and Their Reversibility.

作　　者：毛秦雯[1] 张立藩[1] 马进[1] 

机构地区：[1]第四军医大学航空生理学教研室

出　　处：《航天医学与医学工程》1999年第2期92-96,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金

摘　　要：目的阐明模拟失重下，不同部位动脉血管的结构是否会发生不同性质的重塑变化，这些变化是否可逆。方法用ｖａｎＧｉｅｓｏｎＯｒｃｅｉｎ染色法观察了尾部悬吊４ｗｋ（ＳＵＳ４）、悬吊４ｗｋ后恢复１ｗｋ（ＲＥＣ１）、及对照（ＣＯＮ）大鼠后肢和头颈部动脉血管的形态学改变。结果股动脉及胫前动脉：与ＣＯＮ比较，ＳＵＳ４组的内径（ｄ）与中膜面积（Ａ）均显著减小（Ｐ＜０．０５，Ｐ＜０．０１）；ＲＥＣ１组的ｄ与Ａ尚未完全恢复，但差别已不显著。位于头颈部的颈总动脉与基底动脉的变化恰相反：与ＣＯＮ相比，ＳＵＳ４组的ｄ与Ａ均显著增大（Ｐ＜０．０５，Ｐ＜０．０１）；ＲＥＣ１组的ｄ与Ａ尚未完全恢复。结论模拟失重下，后身的动脉血管可发生萎缩性变化，而在头颈部则为肥厚性变化；解除模拟失重１ｗｋ后仅见部分恢复，提示此种变化是可逆的。Objective The aim of the present study was to test whether medium sized arteries in different body parts are differentially directed to achieve stimulus specific remodeling to adapt local hemodynamic changes induced by tail suspension, and to examine whether these structural changes are reversible. Method Morphological changes of femoral, anterior tibial, common carotid, and basilar arteries from 4 wk tail suspended (SUS 4), 1 wk recovered (REC 1), and control (CON) rats were studied using van Gieson Orcein staining method. Result For the hindquarter arteries, like the femoral and anterior tibial arteries, the lumen diameter (d) and medial tissue area (A) of SUS 4 group were significantly decreased (P<0.05,P<0.01) as compared with that of CON group, and that of REC 1 group were not fully recovered though the differences were not significant. With respect to arteries in the neck region and the brain, the remodeling changes were just in an opposite direction. In SUS 4 group, the d and A of both common carotid and basilar arteries were significantly increased (P< 0.05 ,P<0.01) as compared with that of CON, and not fully restored after 1 wk recovery. Conclusion The structures of medium sized arteries in different body parts remodel differentially in response to local hemodynamic changes during simulated weightlessness and these changes were reversible.

关 键 词：模拟失重 血管脱锻炼 大鼠 动脉 分化重塑 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]