两种抗运动病药物的效果比较  

Comparison Between Two Anti-Motion Sickness Drugs.

作　　者：王静[1] 钱锦康[1] 王宝珍[1] 高建义[1] 石宏志[1] 

机构地区：[1]航天医学工程研究所

出　　处：《航天医学与医学工程》1999年第2期138-140,共3页Space Medicine & Medical Engineering

摘　　要：目的对我们设计的筛选抗运动病药物的动物实验方法进行有效性验证，比较两种抗运动病药物的效果。方法以正负交变加速度旋转刺激，诱发大鼠运动病。１６只大鼠以自身对照进行实验，分别给予大鼠两种抗运动病药物吗嗪及东莨菪碱与右旋苯丙胺合剂（以下简称合剂）后，观察大鼠嗜食高岭土量的变化，评价两种药物的抗运动病效果。结果服两种药后大鼠的食土量都明显减少（Ｐ＜０．０１；Ｐ＜０．０５），比较在同一条件下两种药物组间药效，服合剂后的食土量减少的效果优于服用吗嗪。结论所设计的诱发大鼠运动病模型是可靠的，是实验室研究抗运动病药物的较好方法。两种药物中合剂的抗运动病效果优于吗嗪。Objective To test the validity of an animal model in selecting anti motion sickness drugs,and compare the effects of two drugs. Method Anti motion sickness effects of two drugs (Cyclizine and Scopolamin d amphetamin compound) were abserved in rats with motion sickness (MS) induced by rotatory stimulation and the amount of Kaolin ate by rats was taken as an evaluation criterion. Result The consumption of Kaolin by the rats decreased significantly after administration of both drugs, and the effect of Scopolamin d amphetamin compound was better than those of Cyclizine under the same condition. Conclusion It suggests that the rat model of motion sickness is practical and useful in studying anti motion sickness drugs.

关 键 词：抗运动病药 大鼠 高岭土 运动病 模型 

分 类 号：R852.330.5[医药卫生—航空、航天与航海医学]