复方苯海拉明制剂中樟脑与薄荷脑的体外经皮渗透性研究  

Transdermal penetration of camphor and menthol from compound diphenhystamine preparations

作　　者：盛小茜[1] 周彦彬[1] 邹永华[1] 万茜[1] 何世英[1] 赵玉姣[1] 丁劲松[1] 

机构地区：[1]中南大学药学院药剂学系,长沙410013

出　　处：《中南药学》2010年第5期343-347,共5页Central South Pharmacy

摘　　要：目的研究复方苯海拉明制剂中樟脑与薄荷脑的体外经皮渗透性。方法采用改良Franz直立式扩散池,分别用离体乳猪和裸鼠皮肤为渗透屏障,20%乙醇溶液为接收液,GC法测定接收液中樟脑与薄荷脑的含量,比较2种挥发性成分的体外经皮渗透性。结果离体乳猪皮肤渗透性试验中,乳膏中的樟脑与薄荷脑的渗透系数分别为(0.55±0.15)、(0.23±0.04)cm.h-1,搽剂中2种成分的渗透系数分别为(0.59±0.13)、(0.25±0.03)cm.h-1,而在裸鼠皮肤渗透性试验中,乳膏中的樟脑与薄荷脑的渗透系数分别为(2.91±0.44)、(0.70±0.09)cm.h-1,搽剂中分别为(3.71±1.88)、(1.44±0.65)cm.h-1。结论在乳猪与裸鼠皮肤中,2种制剂中樟脑的渗透系数均大于薄荷脑(P<0.05),而不同制剂间2种挥发性成分的渗透系数差异无显著性(P>0.05)。Objective To investigate the in vitro transdermal penetration of two volatile components,namely camphor and menthol,which were released from the compound diphenhystamine preparations.Methods The penetrating experiments were performed by using skin of piglets and nude mice respectively,which were placed in a modified Franz diffusion cell.The acceptor fluid was 20% ethanol solution.The amounts of camphor and menthol in the acceptor fluid were determined by gas-chromatograpy.We compared their differences in transdermal penetration.Results The permeability coefficients of camphor and menthol were obtained in transdermal penetrating experiments through piglet skins.The parameters were （0.55±0.15）and（0.23±0.04） cm·h-1 from the cream,while （0.59±0.13）and（0.25±0.03） cm·h-1 from the liniment.When nude mice skin was used,the 4 parameters were （2.91±0.44）,（0.70±0.09）,（3.71±1.88）,and （1.44±0.65） cm·h-1,respectively.Conclusion The permeability coefficient of camphor is significantly higher than menthol through the two kinds of animal skin（P0.05）.There is no significant difference between cream and liminent in the same volatile component （P0.05）.

关 键 词：樟脑 薄荷脑 乳膏 搽剂 经皮渗透性 

分 类 号：R927.1[医药卫生—药学] R945