康莱特注射液联合EP方案治疗小细胞肺癌的疗效及不良反应比较  

Comparing EP with EP adding Kanglaite in Treatment and Toxicity for Patient with Small Cell Lung Cancer

作　　者：张娟[1] 周庆丰[1] 李青峰[1] 龚先齐[1] 

机构地区：[1]华中科技大学同济医学院附属襄樊医院,湖北襄樊441021

出　　处：《中医学报》2010年第3期389-390,共2页Acta Chinese Medicine

基　　金：江苏省高校自然科学基础研究资助项目(编号:07KJB360085)

摘　　要：目的:探讨EP方案与康莱特配合EP方案治疗小细胞肺癌的疗效和不良反应。方法:对照组(A组)为21例患者接受EP方案化疗1周期以上;VP-16100mg/m2静脉滴注,d1-3天,DDP25mg/m2静脉滴注,d1-3天。治疗组(B组)为23例患者接受康莱特配合EP方案化疗:EP方案同A组,康莱特100ml静脉滴注,每天2次,d4-24,化疗结束后28-30天评价疗效和不良反应。结果:对照组有效率为42.8%,2例出现3度消化道反应(WHO标准),2例出现3度血液反应,1例出现4度血液反应,卡氏评分提高率19.04%。治疗组有效率为43.4%,1例出现3度消化道反应,1例出现3度血液反应,卡氏评分提高率60.8%。结论:对于小细胞肺癌,EP方案与康莱特配合EP方案治疗小细胞肺癌的疗效统计学无明显差异,但康莱特配合EP方案能明显减轻化疗反应,改善生活质量。Objective：This study was designed to investigate the treatment and toxicity of EP and EP with kanglaite for patients with small cell lung cancer. Menthod Control group （ A group） contained 21 patients. They were treated with EP chemotherapy：VP-16 100 mg/m2,d1-3,DDP 25 mg/m2,d1-3. txamination group （ B group） contained 23 patients. They were treated with EP as A group and kanglaite：100 mg/m2 IV drip,bid,d4-24. Efficiency and toxicity were evaluated at d28-30. Result：The response rate of control group was 42. 8% ,there were two cases of grade three （ WHO） digestive toxicity,two cases of grade three and one case of grade four homological toxicity. The improvement rate of Karnofsky was 19. 0%. The response rate of txamination group was 43. 4% ,there were one case of grade three digestive toxicity and one case of grade three homological toxicity. The improvement rate of Karnofsky was 60. 8%. Conclusion：For small cell lung Cancer,EP and EP with kanglaite have no diffirent efficiency,but EP with kanglaite can light toxicity of chemotherapy and improve life quality.

关 键 词：康莱特 小细胞肺癌 疗效 卡氏评分 不良反应 

分 类 号：R273.934.2[医药卫生—中西医结合]