参桂胶囊再优化处方对大鼠急性心肌缺血的保护作用  

The Use of Prevention Shengui Capsule Prescription Active Ingredient Experimental Optimization

作　　者：贾亚泉[1] 吕越[1] 李宗铎[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《中医学报》2010年第3期475-476,共2页Acta Chinese Medicine

基　　金：河南省科技厅项目(编号:0623030900)

摘　　要：目的:观察参桂胶囊有效成份处方对舌下静脉注射垂体后叶素(pituitrin,PIT)诱发大鼠急性心肌缺血的影响。方法:采用大鼠舌下静脉注射垂体后叶素(0.35U/kg)造成急性心肌缺血模型,观察各给药组注射垂体后叶素后不同时间点第Ⅱ导联心电图T波变化以及血清乳酸脱氢酶(LDH)、肌酸激酶(CK)含量的变化。结果:参桂胶囊有效成份处方能明显对抗垂体后叶素引起的急性心肌缺血的心电图变化,抑制大鼠血清LDH、CK升高。结论:参桂胶囊有效成份处方组具有显著对抗垂体后叶素致大鼠急性心肌缺血的作用。Objective：To study the effect of Shengui Capsule on acute myocardial ischemia induced by pituitrin in rats. Methods：Pituitary（ 0. 35 U/kg） was given to model of acute myocardium ischemia. The changes of theⅡroad electrocardiogram（ T wave） and contents of lactate dehydrogenase（ LDH） ,creatine phosphokinase（ CK） in serum were observed after injection pituitary via sublingual vein. Results：Shengui Capsule ingredients prescription could obviously inhibitthe raise of T-waves in ratmyocardial ischemia induced by pituitrin,and inhibited the levels of serum CK and LDH. Conclusion：Shengui Capsule ingredients prescription have the functions of anti acute myocardium ischemia.

关 键 词：参桂胶囊 垂体后叶素 心肌缺血 药效学 

分 类 号：R285.5[医药卫生—中药学]