幼年特发性关节炎临床特征及生命质量调查  

The clinical features and quality of life study of juvenile idiopathic arthritis

作　　者：李婕[1] 赵晓东[1] 

机构地区：[1]重庆医科大学附属儿童医院,400014

出　　处：《国际儿科学杂志》2010年第3期228-231,共4页International Journal of Pediatrics

摘　　要：目的了解幼年特发性关节炎患儿的急性期临床特征和远期预后，探讨与生命质量相关的临床特征及治疗方案。方法对1997年8月至2007年8月70例幼年特发性关节炎患儿进行回顾性分析及生命质量问卷调查。结果70例患儿中全身型占74．3％，实验室检查缺乏特异性。问卷的内部一致信度（Cronbacha系数0．9599）和构建效度较高。76．8％患儿的生活质量评分显示良好，约17．4％留下永久性关节损害。大于5岁组生命质量明显低于小于5岁组。单用非甾体类抗类药组和非甾体类抗类药联合其他药物组的生命质量差异有统计学意义（P=0．026），发病至正规治疗的时间变量与生命质量总分的相关系数为0．329（P〈0．05）。握变量与“发病至正规治疗的时间、最初受累关节数目”因素显著相关。结论大多数幼年特发性关节炎患儿预后良好。发病至正规治疗的时间、治疗情况、药物依从性、年龄是最常见的影响预后的因素，预后与最初受累关节数目、是否多系统损害也密切相关。Objective To explore the clinical features and long-term prognosis of juvenile idiopathic arthritis （JIA）in children, as well as particular quality of life associated with the clinical features and therapeutic options. Methods Seventy patients from August 1997 to August 2007 were retrospectively reviewed and survey was conducted using a questionnaire indicating quality of life（CHAQ questionnaires and CHQ questionnaire, adjusted appropriatdy） either by phone,letter or out-patient follow-up approach.The manner of correlation and logistic regression was used to analyze quality of life associated with the clinical features and therapeutic options.Results （1）The majority （74.3%） of patients were diagnosed as systemic onset JIA. The Cronbach Alpha coefficient of questionnaire is 0. 9599, with a higher inemal consistency reliability. The scales validity also had the higher construction. Sixty nine eases with 76.8 percent of the score showed good quality of life. Quality of life in children less than 5 years old was signifieandy different from those more than 5-year old（ P 〈 0.05）.The rank sum test of single-use NSAIDs group and NSAlDs adding other medicine group suggested that the two groups had differences in quality of life（ P = 0.026） .The eorrelation coefficient between the variables of time from onset to formal treatment and quality of life scores was 0.329（ P 〈 0.05）, and ＂walking＂as the dependent variable for the regression analysis showed regression coefficient was 0.15（P =0.016）. The variable grip had the significant relationship with the ＂disease onset to regular treatment, the initial number of joint involvement＂ respectively. Conclusion Systemic oneset JIA is the most common type of JIA. Most of JIA patients have a good prognosis.The major factors which may cause the decline in the quality of life are age,duration without therapy after the disease onset, and the compliance to medication. To achieve a better prognosis,more aggressive therapy may be needed and indivi

关 键 词：幼年特发性关节炎 健康相关生命质量 

分 类 号：R725.9[医药卫生—儿科]