Th17细胞及其在哮喘等过敏性疾病中的作用  

Th17 cells and its roles in asthma and allergy diseases

作　　者：赵灵芝(综述)[1] 卢美萍(审校)[1] 

机构地区：[1]浙江大学医学院附属儿童医院呼吸科,310003

出　　处：《国际儿科学杂志》2010年第3期270-272,共3页International Journal of Pediatrics

基　　金：浙江省医药卫生科学研究基金资助（N20080606）;浙江省自然科学基金资助（Y2090339）

摘　　要：Th-17细胞作为独立的CD4^＋T细胞谱系，分泌一系列特有的免疫调节因子，在各种免疫介导的疾病中发挥重要作用。研究证明，Th17分泌的特征性细胞因子IL-17，参与哮喘等过敏性疾病的诱导，介导其炎症过程。IL-17诱导产生趋化因子IL-8，在严重哮喘的气道中募集中性粒细胞浸润，而且可能对哮喘患者气道腺体的高分泌、气道高反应性及气道重塑起作用。假设Th17细胞过度活化和过敏性气道炎症之间存在密切关联，那么针对，Th17细胞的治疗方法将有广阔前景，但其临床应用有待进一步研究。Th17 cells were identified as an independent lineage of CD4^＋ T cells that secrete a distinctive set of immunoregulatory cytokines, which play an important role in the pathogenesis of a diverse group of immune-mediated diseases. Recent data in humans and mice trials suggest that as the hallmark cytokine of Th17 cells, IL-17 involved in the inducement and the inflammation of allergy, such as asthma. IL-17 induces chemokine IL-8, and prominently recruits neutrophils in the airways in severe asthma exacerbations and may contribute to airway gland hypersecretion, bronchial hyper-reactivity and airway wall remodelling in asthma. Given the strong association between excessive Thl7 activity and human diseases,new therapeutic approaches targeting Th17 ceils are highly promising, but the potential clinical application need further investigation.

关 键 词：过敏性疾病 变态反应性疾病 哮喘 IL-17 Th-17 

分 类 号：R392.12[医药卫生—免疫学]