米安色林与氟西汀抗抑郁焦虑作用研究  

A control study of mianserin and fluoxetine in the treatment of depression and anxiety

作　　者：张明松[1] 张慧芳[1] 赵艳华[1] 宋丽[1] 

机构地区：[1]河南驻马店市精神病医院,驻马店463000

出　　处：《中国实用神经疾病杂志》2010年第9期29-31,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探索米安色林在治疗中伴有焦虑症状的抑郁症的疗效与安全性。方法将69例难治性抑郁症同时伴有焦虑症状的患者分为米安色林组35例,氟西汀组34例。观察2周,与治疗前和治疗后1、2、4及8周末采用汉密尔顿抑郁量表(HAMD-17)及汉密顿焦虑量表(HAMA)评定疗效,用副反应量表(TFSS)评定不良反应。结果米安色林组显效78%,氟西汀组显效75%,米安色林组不良反应相对较少。结论米安色林治疗伴发焦虑症状的抑郁症疗效较好,且起效快,不良反应少。Objective To investigate the efficacy and safety of mianserin in the treatment of patients with refractory depression and anxiety. Methods A total of patients with refractory depression and anxiety were randomly assigned to 8 weeks treatment with mianserin （n=35） or fluoxetine （n=34） and changes from baseline in the Hamilton rating scale for depression （HAMD-17）, total scores of two groups, and treatment emergent symptom scale （TESS） were compared at 1st week before treatment and 2nd,4th,8th week after treatment. Results The significant efficacy rate of mianserin group was 78%, whilethat in the fluoxetine group was 75 %. There were fewer side effects in the mianserin group than the other group. Conclusion Mianserin is better than fluoxetine in the treatment of refractory depression and anxiety, it shows better efficacy and less side effects. It is beneficial to improve the therapeutic compliance of depressive patients.

关 键 词：抑郁 焦虑 氟西汀 米安色林 

分 类 号：R971.4[医药卫生—药品]