新型带瓣膜肺动脉瓣支架的研制及体外经导管植入实验  

Preparation of valved pulmonary stent and in vitro implantation to pulmonary valve position through catheter

作　　者：陈翔[1] 白元[1] 朱玉峰[1] 姜海滨[1] 秦永文[1] 

机构地区：[1]第二军医大学长海医院心内科,上海200433

出　　处：《国际心血管病杂志》2010年第3期180-182,共3页International Journal of Cardiovascular Disease

基　　金：国家高科技研究发展863计划(2006AAOZZ41D7)

摘　　要：目的:评价自行研制的新型带瓣膜不锈钢支架经导管植入的可行性。方法:自行设计圆柱形网状支架,委托北京乐普公司使用由医用316L不锈钢激光雕刻而成。将新鲜的猪心包经脱细胞处理后给予0.6%戊二醛浸泡36h,生理盐水洗净,裁剪成人工瓣膜,缝合在不锈钢支架上,制成带瓣膜支架。取离体狗心脏标本,直视下将压缩好的带瓣膜支架球囊经16F鞘管由右室心尖部送入狗肺动脉瓣位置,撑开球囊,释放支架,退出球囊导管。结果:自制的带瓣膜动脉瓣雕刻支架在球囊支撑下可完全打开,牢固地置于原肺动脉瓣位置,人工瓣膜启闭功能好。结论:此带瓣膜雕刻支架设计合理,经球囊导管可完全打开,瓣膜功能良好,可用于动物体内植入实验研究。Objective：To develop valved stent and to evaluate the feasibility of its trans-catheter implantation to the pulmonary artery. Methods：A new valved stent made from 316L stainless steel was designed. Fresh porcine pericardium was decellularized,treated with 0.6 % glutaraldehyde solution for 36 h,cleaned with physiological saline, and sutured by hand into the stainless steel stent. The valved stent was compressed on a balloon catheter, pulled into a 16-French sheath, and positioned in the pulmonary valve of isolated dog heart via the right ventricle. Thereafter the operator inflated the balloon and released the stent, then withdrew the balloon catheter. Results：The prepared valved pulmonary stent could be expanded completely and stably positioned over the native valves, the closure and opening of the valved pulmonary stent leaflets were satisfactory. Conclusion：This valved stent is well-designed and allows for pulmonary valve implantation over the native valves through catheter,despite that it needs to be evaluated further in vivo.

关 键 词：肺动脉瓣 心脏瓣膜假体植入 不锈钢支架 

分 类 号：R654.2[医药卫生—外科学]