生物可降解聚合物支架与永久聚合物支架治疗冠心病的随访研究  

Clinical follow-up of biodegradable polygmer stents (EXCEL) and durable polymer stents (CYPHER) in treating coronary artery disease

作　　者：张福[1] 白明[2] 李强[2] 潘明[2] 汪涛[2] 药素毓[2] 黄晏[2] 张钲[2] 

机构地区：[1]兰州大学第一临床医学院,730000 [2]兰州大学附属第一医院心脏中心

出　　处：《国际心血管病杂志》2010年第3期183-185,共3页International Journal of Cardiovascular Disease

摘　　要：目的:比较国产生物可降解希罗莫司支架(EXCEL)与进口永久聚合物希罗莫司支架(CYPHER)在冠心病患者中应用的安全性及有效性。方法:回顾分析同期植入EXCEL支架治疗的230例和植入CYPHER支架的161例冠心病患者,对比分析两组患者PCI操作成功率、术后1年内主要不良心脏事件(MACE)发生率及支架内血栓事件发生率。结果:两组在基本临床情况、冠脉病变特征及主要介入技术指标等方面均无统计学差异;两组手术操作成功率分别为99.6%和99.4%;术后随访1年MACE发生率EXCEL组(5.8%)略高于CYPHER组(4.6%),但两组比较差异无统计学意义(P>0.05);CYPHER组支架内血栓事件发生率0.7%,而EXCEL组术后无支架内血栓事件发生,但两组比较差异无统计学意义(P>0.05)。结论:生物可降解希罗莫司涂层支架(EXCEL)治疗冠心病安全有效,各项指标与CYPHER支架相比无明显差异。Objective：To compare the safety and efficacy of biodegradable polymer sirolimus-eluring stent （EXCEL） and durable polymer sirolimus-eluting stents （CYPHER） in the treatment for coronary artery disease. Methods： This is a retrospective case-control study in a single centre. A cohort of 230 patients with CAD treated with EXCEL stent and a subset of 161 CAD patients treated with CYPHER stent from January 2007 to April 2008 were followed up. The results from 12 months of follow- up were analyzed by comparing procedural success rate, MACE and stent thrombosis. Results： Two groups were similar in main baseline clinical data and major angiography characteristics. The procedural success rate was 99.6% in EXCEL group and 99.4% in CYPHER group, respectively （P〉0.05）. The incidence of MACE at one-year follow-up was 5. 8% in EXCEL group and 4.6% in CYPHER group （P〉 0.05）. Stent thrombosis occurred in 1 patient （0.7%） in CYPHER group and in no patient in EXCEL group, without significant difference （P〉0.05）. Conclusion：Implantation of the EXCEL stent in patients with coronary artery disease is safe and effective, with no difference compared with that of the CYPHER stent in one-year follow-up outcomes.

关 键 词：EXCEL支架 CYPHER支架 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]