早孕药物流产后动态观察血清性激素变化的临床价值  

Dynamically observing the value of the changes of serum sex hormone levels of early pregnancy after drug-induced abortion

作　　者：赵洪刚[1] 董华[1] 顾燕[1] 张遵城[1] 

机构地区：[1]天津医科大学第二医院核医学科,300211

出　　处：《国际放射医学核医学杂志》2009年第5期283-285,共3页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的探讨动态观察早孕药物流产孕妇血清13一人绒毛膜促性腺激素（p．HCG）、雌二醇（E）及孕酮（P）水平变化的临床价值。方法对55例停经时间35～39d、证实早孕而要求终止妊娠的孕妇给予米非司酮配伍米索前列醇，使用化学发光免疫分析法对服药前后外周血B—HCG、E及P水平动态监测，进行回顾性分析。结果所有早孕妇女孕囊排出后7d时B．HCG、E、P水平均明显降低（tβ-HCG=4．845，tE=7．655，tp=11．390，P〈0．05）。孕囊排出后7d时E和P水平迅速下降到卵泡期水平，14d较7d时雌二醇明显上升（tE=9．089，P〈0．05）；21d较14d时P有明显升高（tp=2．910，P〈0．05）。结论化学发光免疫分析法测定血清β-HCG、E和P水平可以间接评价米非司酮配伍米索前列醇药物流产的疗效，并预测药流后阴道出血时间是否延长，从而早期判断预后，为尽早给予临床干预提供依据。Objective To observe the value of the changes of serum β-human chorionic gonadotropin （β-HCG）, estradiol（E）, progesterone（P） Levels of early pregnancy after drug-induced abortion dynamically. Methods Assessing 55 women proved pregnant by urine or blood HCG retrospecticly, who had terminated their pregnancy by mifepristonr and misoprostol. Meanwhile the serum levels of β-HCG, E, P were monitored dynamically. Results Among the 55 patients, the levels of β-HCG, E and P had significant decreased （tβ HCC=4.845, tE=7.655, tp=11.390, P〈0.01）. On the 7th day, the levels of E and P decreased to the level of follicle phase. The level of E on the 14th day was higher than that of 7th day （tE=9.089, P〈 0.05） ; the level of P was higher than that of 14th day （tp=2.910, P〈0.05）. Conclusion Detecting the serum hormone＇ s levels after drug-induced abortion by chemiluminescent immunoassay, we can assess indirectly the value of administration of mifepristone and misoprostol, predict the prolonged vaginal bleeding after drug-induced abortion, and the outcome of the treatment, which determine wether need another curestage.

关 键 词：流产 人工 绒毛膜促性腺激素 β-亚单位 人 雌二醇 孕酮 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]