HIFU肿瘤治疗中的非线性效应对温度分布影响的研究  

The Study of the Influence of Nonlinear Effect on Temperature Distribution During HIFU Tumor Treatment

作　　者：胡继文[1,2] 钱盛友[2] 付茂林[1] 贾鹏[1] 吴喜军[1] 

机构地区：[1]南华大学数理学院,湖南衡阳421001 [2]湖南师范大学物理与信息科学学院,湖南长沙410081

出　　处：《南华大学学报（自然科学版）》2009年第4期66-69,共4页Journal of University of South China：Science and Technology

基　　金：湖南省自然科学基金资助项目(02JJY2059)

摘　　要：本文以凹球面自聚焦换能器为声源,通过计算非线性波动方程和生物热传导方程,得到了生物组织中聚焦区的温度场分布.结果表明:非线性效应对焦域温度分布有着重要的影响.它一方面造成声焦点前移,并使声焦点与几何焦点的距离随聚焦深度增加而增大;另一方面,非线性效应的存在导致聚焦区温度分布在治疗过程中由规则的椭球形变成不规则的"蝌蚪"形或"龟"形,这种温度变化随生物组织的非线性特性加强而愈显著.本文从非线性角度对此现象给予了解析.The temperature field in focused region is obtained by solving nonlinear wave equation and bio-heat equation in the sound field produced by a self-focused concave spherical transducer.The results show that the nonlinear effect plays an important role in the temperature distribution of focal region.On the one hand,the nonlinear effect leads to the focusing point to move forward and the distance between the focusing point and geometrical focus to increase with increasing the focusing depth.On the other hand,it causes the temperature distribution to deform from ＂cigar＂ shape into ＂tadpole＂ shape or ＂turtle＂ shape and the deformation will become more remarkable with the nonlinear property getting intensive.Simultaneously,these results are analyzed.

关 键 词：高强度聚焦超声 非线性效应 肿瘤治疗 

分 类 号：O422.2[理学—声学] TB552[理学—物理]