克拉霉素联合替硝唑治疗小儿HP相关性胃炎的临床研究  

作　　者：杨峻[1] 廖伟强[1] 邓慧延[1] 陈燕霞[1] 

机构地区：[1]东莞市厚街医院儿科,523945

出　　处：《当代医学》2010年第15期45-46,共2页Contemporary Medicine

摘　　要：目的探讨克拉霉素联合替硝唑治疗小儿幽门螺杆菌(HP)相关性胃炎的疗效。方法选取14C尿素呼吸试验及血清HP-IgG测定均为阳性的患儿60例。将60例患儿随机分为治疗组(34例)和对照组(26例),两组基础治疗相同。治疗组给予克拉霉素15mg/(kg·d)及替硝唑10mg/(kg·d),每天2次,疗程为1周。对照组给予阿莫西林30mg/(kg·d)及甲硝唑20mg/(kg·d),每天2次,疗程为2周。观察记录HP根除情况、主要症状改善情况及不良反应。结果治疗组与对照组总有效率分别为97.1%、80.7%,HP根除率分别为91.2%、73.1%,两组比较,均有显著性差异(P<0.05)。结论应用克拉霉素联合替硝唑治疗小儿HP相关性胃炎,疗效明显优于阿莫西林联合甲硝唑组。Objective To study the curative effect of Clarithromycin and tinidazole to explore co-treatment of children with HP related gastritis.Methods 60 patients were randomly divided into two groups：the therapeutic group and the controlgroup equally with the same basal treatment.14C urea breath test and determination of serum HP-IgG are positive.The therapeutic group was treated by Clarithromycin and tinidazole;while the control group by Amoxicillin and metronidazole.Treatment 1-2 weeks,HP eradication and the main symptom improvement were observed and recorded.Results The treatment group and control group,the total effective rates were 97.1%,80.7%,HP eradication rates were 91.2%,73.1%,the two groups were significantly difference（P〈0.05）.Conclusion Application of combined clarithromycin and tinidazole in treatment of children with Helicobacter pylori-associated gastritis,efficacy is superior to amoxicillin combined with metronidazole.

关 键 词：幽门螺杆菌 小儿胃炎 联合治疗 

分 类 号：R725.7[医药卫生—儿科]