复方脑脉通有效部位与药材指纹图谱相关性研究  

Correlation between fingerprint peaks and Compound Naomaitong 's effective fraction and its relevant herbs

作　　者：冯素香[1] 王淑美[2] 梁生旺[2] 李建生[1] 

机构地区：[1]河南中医学院,河南郑州450008 [2]广东药学院,广东广州510006

出　　处：《中成药》2010年第5期701-704,共4页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金资助项目(30371812)

摘　　要：目的:建立脑脉通(大黄、人参、葛根)有效部位的HPLC指纹图谱,研究复方与组方药材指纹图谱色谱峰相关性。方法:采用HPLC-PDAD方法,建立脑脉通有效部位及各药材在203nm检测波长下的指纹图谱,以色谱峰保留时间为考察指标,对复方指纹图谱色谱峰归属进行分析。结果:建立了脑脉通复方有效部位的HPLC对照指纹图谱,标示出36个共有指纹峰,对复方特征峰进行了归属分析,确定了14个特征峰的药材归属。结论:该指纹图谱有助于提高脑脉通有效部位的质量控制水平。AIM：To establish the HPLC fingerprint of Compound Naomaitong effective parts,and to study the correlation analysis between fingerprint peaks and the effective fraction and its relevant herbs. METHODS：The chromatographic fingerprints of the effective fraction and the relevant fractions of its herbs were configured by HPLC/PDAD analysis. The relative deviation of retention time was utilized as indices to evaluate the correlation, the wavelength was set at 203 nm. RESULTS：The fingerprint of Compound Naomaitong effective parts was established and 36 copossessing fingerprint peaks were indicated. The assignment results of 14 peaks effective parts of fraction were indicated. CONCLUSION：The quality of Compound Naomaitong effective parts can be controlled by the HPLC fingerprint.

关 键 词：脑脉通 有效部位 指纹图谱 相关性研究 HPLC 

分 类 号：R284.1[医药卫生—中药学]