盐酸去氢骆驼蓬碱乳膏处方筛选及其止痒药效学研究  

Optimization of prescription and anti-pruritic effect of harmine hydrochloride cream

作　　者：丁志荣[1] 滕亮[1] 戴秀勇 于富生 

机构地区：[1]新疆医科大学药学院,新疆乌鲁木齐830054 [2]新疆华圣元医药科技有限公司,新疆乌鲁木齐830011

出　　处：《中成药》2010年第5期753-757,共5页Chinese Traditional Patent Medicine

摘　　要：目的:优选盐酸去氢骆驼蓬碱乳膏处方组成并对其止痒药效学进行研究。方法:采用以乳膏的外观、均匀性、涂布性、黏度、粒径、高温试验结果、离心试验结果为评价指标的综合评分法,建立乳膏客观评价体系,以均匀试验设计优选盐酸去氢骆驼蓬碱乳膏处方组成。以皮炎平软膏为阳性对照品,观察盐酸去氢骆驼蓬碱乳膏对磷酸组胺和五羟色胺所致小鼠皮肤瘙痒的止痒作用。结果:优化后的乳膏处方为:单硬脂酸甘油酯(8%)、凡士林(5%)、蜂蜡(6.1%)、司盘-60(1.1%)、吐温-80(1.9%)。盐酸去氢骆驼蓬碱乳膏对磷酸组胺、五羟色胺引起的瘙痒均有抑制作用,且高、中剂量药物的止痒效果优于皮炎平软膏。结论:验证试验表明该乳膏处方合理、稳定、可行,能有效对抗磷酸组胺、五羟色胺引起的瘙痒。AIM： To select the prescription of harmine hydrochloride cream and to study the anti-itching effect of harmine hydrochloride cream. METHODS： A comprehensive score system,including appearance,homogeneity,coating performance,viscosity,particle diameter,temperature-resistant test,and centrifugal effect were established as evaluative criteria. Then uniform design was used for selecting the prescription of harmine hydrochloride cream. The histamine phosphate and 5-hydroxytryptamine （5-HT） were used to induce mouse cutaneous pruritus. Then the anti-pruritic effect of harmine hydrochloride cream in contrast to Piyanping Ointment as control group. RESULTS： The optimized prescription was as follows： 8% of monostearin,5% of Vaseline,6. 1% of beeswax, 1. 1% of Span-60,1. 9% of Tween-80. The local application of harmine hydrochloride cream could alleviate the itching induced by histamine phosphate and 5-HT,respectively. And the anti-pruritic effect of harmine hydrochloride cream was stronger than the effect of the positive control group. CONCLUSION： The prescription of the harmine hydrochloride cream is available,reasonable,and reproducible. The harmine hydrochloride cream has the anti-pruritic effect.

关 键 词：盐酸去氢骆驼蓬碱 乳膏 处方 止痒 

分 类 号：R944[医药卫生—药剂学]