复方三氮唑核苷注射液对大白鼠的亚慢性毒性试验  

Subchronic Toxicity Test of Ribavirin Compound in Rat

作　　者：龚倩[1,2,3] 贾冬舒[1,2,3] 马红霞[1,2,3] 陈威 

机构地区：[1]吉林农业大学动物科学系 [2]解放军农牧大学 [3]长春兴和动物制药有限公司

出　　处：《吉林农业大学学报》1999年第1期74-76,共3页Journal of Jilin Agricultural University

摘　　要：将复方三氮唑核苷注射液按高、中、低剂量分别给大白鼠皮下注射，每天１次，连续注射３０ｄ，观察试验鼠的生理状态及活动情况，测定增重及血液生理生化指标，并进行病理解剖及病理组织学检查。结果表明，复方三氮唑核苷注射液对大白鼠的生理活动、血液生理生化指标均无不良影响；病理组织学检查，仅高剂量组有１０％大白鼠发生肾小管上皮细胞轻度颗粒变性，其它组各器官均未见异常。rats randomly divided into 4 treatment groups. They were provided ribavirin compound 27.29 (LD 50 1/10), 13.64 (LD 50 1/20), 9.10 (LD 50 1/30)) and 0 mg/100g body weight by hypodermic injection one time a day, respectivily. The experimental period were 30 days . The research results showed that ribavirin compound has no poisonous effects in normal activities, physiological index and biochemical index in rats.

关 键 词：复方三氮唑核苷 注射液 大白鼠 毒性试验 

分 类 号：S859.7[农业科学—临床兽医学] S865.12[农业科学—兽医学]