不同厂家枳实配方颗粒中黄酮类活性成分的含量对比研究  

Content comparison of active flavonoids in Zhishi Granules from different manufactories

作　　者：陈彦[1,2] 辛然[1,2] 贾晓斌[1] 何学娟[1] 

机构地区：[1]江苏大学药学院,镇江212013 [2]江苏省中医药研究院中药新型给药系统重点实验室,国家中医药管理局中药释药系统重点研究室,南京210028

出　　处：《中华中医药杂志》2010年第6期914-916,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药科学技术研究专项(No.06-07ZP18);江苏省中医药科学技术研究专项(No.HZ07080)~~

摘　　要：目的:对不同厂家生产的枳实配方颗粒中黄酮类活性成分的含量进行比较。方法:建立超高效液相色谱法同时测定枳实配方颗粒中3种黄酮类成分柚皮苷、橙皮苷、新橙皮苷的含量。结果:3个厂家生产的枳实配方颗粒中柚皮苷和新橙皮苷含量差异较大,其中A厂家3批样品中柚皮苷和新橙皮苷含量最高,平均为1.538%和1.853%,B厂家的2批样品中这2成分平均含量只为A厂家的1.2%和1.0%,C厂家2批样品中2成分平均含量分别为A厂家的49%和48%,而3个厂家的样品中橙皮苷的含量较为一致,平均含量范围为0.070%-0.115%。结论:不同厂家生产的枳实配方颗粒中黄酮类成分的含量有显著差异。Objective：To compare the content of the active flavonoids in Zhishi Granules from different manufactories.Methods：An ultra high performance liquid chromatography method was developed to determine the content of naringin,hesperidin,and neohesperidin.Results：Significant difference was found among these three manufactories in the content of naringin and neohesperidin.The content of naringin and neohesperidin in the granules from manufactory A were the highest,which were 1.538% and 1.853% respectively,whereas the content of naringin and neohesperidin in the granules from manufactory B were the lowest,being 1.2% and 1.0% of that of manufactory A.The content of these two constituents in the granules from manufactory C were 49% and 48% of that of manufactory A.In addition,the content of hesperidin in the granules,ranged from 0.070% ～ 0.115%,was almost the same from different manufactories.Conclusion：The content of flavonoids in Zhishi Granules from different manufactories had significant difference.

关 键 词：枳实配方颗粒 黄酮类成分 超高效液相色谱 含量对比 

分 类 号：R284[医药卫生—中药学]