4-取代的脯氨酰胺催化的不对称直接羟醛缩合反应  

Direct Asymmetric Aldol Reaction Catalyzed by 4-Substituted Proline Amide

作　　者：何龙[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637009

出　　处：《西华师范大学学报（自然科学版）》2010年第2期207-210,共4页Journal of China West Normal University(Natural Sciences)

基　　金：西华师范大学科研启动基金资助项目(05B022)

摘　　要：研究了脯氨酰胺类催化剂催化丙酮与醛的不对称直接Aldol反应,结合我们曾经报道的环己酮与醛的直接Aldol反应的反应结果,发现二苯基氨基醇衍生的脯氨酰胺催化剂四位的结构改造对其催化性能有很大的影响,这为我们针对不同的Aldol反应设计相应的催化剂提供了重要思路.We reported a Proline Amide derived from Trans -4 -hydroxy - L - Proline and （ 1S, 2S） - 1, 2 - di- phenyl - 2 - aminoethanol would catalyze direct asymmetric aldol reaction between acetone and a wide scope of aldehydes in moderate yields and enantioseleetivities of up to 95% ee. Moreover, the results and those we reported before, revealed that the modification of the 4 - position on pyrrolidine structure can remarkably influence the catalytic ability. Basing on this result, we can design new efficient catalysts for different aldol reactions with a variety of subsitituented aldehyde.

关 键 词：ALDOL反应 脯氨酰胺 不对称 催化剂 

分 类 号：O626.1[理学—有机化学]