转化生长因子β1血清水平与左向右分流型先天性心脏病肺动脉压力的相关性探讨  

A study of experiment TGF-β1 the left to right flow of congenital heart disease

作　　者：郭俊晓[1] 刘志平[1] 

机构地区：[1]内蒙古医学院第一附属医院心胸外科,呼和浩特010050

出　　处：《中国医药》2010年第6期499-500,共2页China Medicine

摘　　要：目的 通过对先天性心脏病及先天性心脏病伴肺动脉高压（PH）患者血清中转化生长因子β1（TGF-β1）水平的检测,进一步明确其与先天性心脏病伴肺动脉高压的关系.方法 采用实验研究策略,利用酶联免疫吸附测定（ELISA）方法测定48例先天性心脏病患儿（4组分为无PH组、轻度PH组、中度PH组、重度PH组各12例）静脉血清中TGF-β1的水平变化.结果 TGF-β1在重度PH组（2.01±0.26）μg/L明显高于中度PH组（1.80±0.56）μg/L、轻度PH组（1.34±0.11）μg/L及无PH组（0.82e±0.11）ug/L（P＜0.01）,尤以重度与无PH之间较为明显,差异具有统计学意义（P＜0.01）.结论 左向右分流型先天性心脏病患儿TFG-β1参与先天性心脏病伴肺动脉高压的形成,可能对先天性心脏病伴肺动脉高压程度的评价、手术指征及预后起着重要作用.Objective To investigate the relationship between development pulmonary hypertension （PH）and TGF-β1 in the congenital heart disease（CHD） and PH patients.Methods Serum of vain TGF-β1 concentration of CHD was measured by ELISE assy in different pulmonary hypertension and time （among the non-PH group and mild,moderate and servere PH groups every 12）.Results There were significant changes in serum levels of TGF-β1 at the different PH.in the non-PH and mild, moderate PH, there were significant difference between the non-PH and mild,moderate PH and servere PH groups levels of TGF-β1 , especially, there is a noteable change between the non-PH and servere PH groups （P〈0.01）.Conclusions TGF-β1 in the left to right flow CHD patient has a great effect on the shaping and development of PH, and check the factor concentration may estimate the PH level of the CHD, operation standard and prognosis.

关 键 词：先天性心脏病 左向右分流 转化生长因子Β1 

分 类 号：R541.1[医药卫生—心血管疾病]