防治急性阑尾炎围手术期感染4种方案的最小成本分析  

Cost-effectiveness Analysis of 4 Preventive Treatments in Perioperative Period of Acute Appendicitis

作　　者：梁海慧[1] 邱凯峰[1] 余慕婉[1] 黄东全[1] 

机构地区：[1]中山大学附属第二医院,广东广州510120

出　　处：《今日药学》2010年第5期52-53,共2页Pharmacy Today

摘　　要：目的观察不同方案的抗菌药物防治急性阑尾炎围手术感染的经济效果差别。方法100例行阑尾切除术的患者随机分为4组,头孢哌酮/舒巴坦(1∶1)联合甲硝唑组,头孢曲松钠联合甲硝唑组,头孢呋辛联合甲硝唑组,左氧氟沙星联合甲硝唑组,均在手术前30 min给药,术后连续2 d用药。采用药物经济学最小成本进行分析。结果4组患者的疗效均无统计学差异。成本最低的为左氧氟沙星联合甲硝唑组。结论左氧氟沙星联合甲硝唑是这4种方案中最佳的防治方案。Objective To evaluate the different economic effects of 4 kinds of preventive treatments in the perioperative period of acute appendicitis. Methods The cost-effectiveness method of pharmaeoeeonomies was adopted in the retrospective analysis of the following 4 treatment schemes ： cefoperazone and metronidazole, ceftriaxone and metronidazole, cephroxine and metronidazole, and levofloxacine and metronidazole. Results The treatment effect had no statistic difference among patients from 4 groups. The cost effectiveness ratio of levofloxacine and metronidazole was the minimum. Conclusion The best preventive treatment in the perioperative period of acute appendicitis patients is levofloxacine and metronidazole.

关 键 词：急性阑尾炎 抗菌药 药物经济学 最小成本分析 

分 类 号：R956[医药卫生—药学]