子痫前期脐血流异常与围生儿预后相关性分析  

Relationship between abnormal umbilical blood flow and perinatal outcomes of preeclampsia patients

作　　者：李寒松[1] 李炜[1] 王少为[1] 

机构地区：[1]卫生部北京医院妇产科,北京100730

出　　处：《中国生育健康杂志》2010年第2期67-70,共4页Chinese Journal of Reproductive Health

摘　　要：目的探讨子痫前期患者脐动脉血流改变与围生儿预后的相关性。方法回顾性分析2006年1月至2009年6月在本院产前检查至分娩的92例子痫前期患者的脐动脉血流参数S/D值、血流波动指数(PI)、阻力指数(RI)及新生儿出生时体重、Apgar评分、胎盘重量等的变化。92例患者中轻度子痫前期57例、重度子痫前期35例。随机选择同期正常妊娠分娩、无产科并发症及合并症的100例患者作为正常对照组,观察S/D、PI、RI值及母婴结局。结果随着子痫前期病情严重程度的增加,S/D、PI、RI值均呈增高趋势,重度子痫前期组脐血流参数明显高于正常组,差异有统计学意义(P<0.01);轻度子痫前期组与正常组比较增高趋势不明显,差异无统计学意义(P>0.05)。随着脐血流参数的增加,重度子痫前期的新生儿出生时平均体重、Apgar评分、胎盘重量均低于正常组,差异有统计学意义(P<0.01)。脐血流异常的重度子痫前期患者的胎儿生长受限发生率、围生儿死亡率明显高于正常对照组,差异有统计学意义(P<0.01);轻度子痫前期组的上述变化与正常对照组比较,差异无统计学意义。结论重度子痫前期脐血流参数S/D、PI、RI值可以作为判断胎儿宫内状况的指标,为胎儿预后提供了简易无创的监测手段。Objective To investigate the relationship between umbilical blood flow changes and the pregnancy outcomes among women with preectampsia. Methods There were 92 preeclampsia patients in the department of obstetrics in our hospital from January 2006 to June 2009. Parameters of umbilical arterial blood flow including S/D ratio, pulsatility index （ PI）, resistanice index （ RI）, the average birth weight, Apgar score and placental weight changes were analyzed retrospectively in 92 preeclampsia patients （including 57 mild and 35 severe cases） and 100 women with normal pregnancy as the control group. Results The umbilical arterial blood flow parameters tended to increase with the severity of preechlmpsia, and the values of these parameters were significantly higher in patients with severe preeclampsia than in the control group （ P 〈 0. 01 ）, although no significant differences were observed between the mild preeclampsia group and the control group （ P 〉 0.05 ）. The mean birth weight of the newborns, Apgar scores, and placental weight were significantly lower （ P 〈 0.01 ）, and the incidence of fetal growth restriction and perinatal mortality were significantly higher in the severe preeclampsia group than in the control group （P 〈 0. 01 ）. No significant differences were found in these parameters between the mild preeclampsia group and the control groups （P 〉 0. 05）. Conclusion Umbilical artery blood flow parameters as indicators for determining the fetal status can be used to predict pregnancy outcomes of severe preeclampsia.

关 键 词：子痫前期 彩色多普勒超声 脐动脉血流比值 围生儿预后 

分 类 号：R714.7[医药卫生—妇产科学]