腹膜纤维化大鼠模型研究进展  

Advances in Peritoneal Fibrosis Rat Model

作　　者：项协隆[1,2] 林沁[1,2] 

机构地区：[1]福建医科大学福总临床医学院 [2]南京军区福州总医院肾内科,福州320025

出　　处：《医学综述》2010年第10期1445-1447,共3页Medical Recapitulate

基　　金：福建省科技厅重点基金(2008Y0085)

摘　　要：腹膜纤维化大鼠模型是研究腹膜纤维化的重要工具。腹膜纤维化大鼠模型按照造模方法不同主要分为细菌性腹膜炎致腹膜纤维化大鼠模型、化学性腹膜炎致腹膜纤维化大鼠模型、非生物相容性腹膜透析液致腹膜纤维化大鼠模型和转基因动物腹膜纤维化大鼠模型4类。各个研究组所采用的腹膜纤维化模型在诱导方法、腹膜功能评价及取材部位等方面均各不相同,因此建立稳定、可靠、符合临床的大鼠模型有重要意义。Rat model is an essential research tool of peritoneal fibrosis.According to the model-making methods of peritoneal fibrosis rat model,four types of models are available,namely peritoneal fibrosis model of bacterial peritonitis,peritoneal fibrosis model induced by chemical peritonitis,peritoneal fibrosis model for the bioincompatible peritoneal dialysate and transgenic rat model of peritoneal fibrosis.Research groups working with peritoneal fibrosis models vary substantially in the induction method,measures of peritoneal function and histological sampling.It is important to develop several rat models of peritoneal fibrosis,which are stable,reliable,and with clinical characteristics similar to those seen in peritoneal fibrotic patients.

关 键 词：大鼠 模型 动物 腹膜纤维化 

分 类 号：R459.5[医药卫生—治疗学]