肿瘤疼痛的基因治疗  

Gene Therapy of Cancer Pain

作　　者：夏辉[1] 张登文[1] 王学仁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院麻醉科教研室,武汉430030

出　　处：《医学综述》2010年第10期1505-1507,共3页Medical Recapitulate

摘　　要：肿瘤通常会引起疼痛,而目前的常规药物止痛常不能满意地缓解肿瘤患者的疼痛症状,并且或多或少存在一些不良反应。近年来,随着肿瘤疼痛动物模型的不断建立,研究方法的不断改进,肿瘤痛机制的深入研究,在上调抗痛基因表达与下调疼痛基因表达的基本策略的基础上,肿瘤疼痛基因治疗也获得很大的进展。这给临床治疗肿瘤疼痛带来新的希望。现就肿瘤疼痛的基因治疗进行综述。Tumors usually cause pain but the current conventional analgesics do not satisfactorily relieve pain in patients with cancer,with some side effects otherwise.In recent years,with the continual establishment of animal models of cancer pain,the improvement of research technology and methods,and the further study of mechanisms of cancer pain,gene therapy for cancer pain has achieved the remarkable progress based on the basic strategies,upregulating the expression of anti-allodynic gene and downregulating the expression of allogenic gene.It gives us new hope in clinical treatment of cancer pain.In this paper,gene therapy of cancer pain is reviewed.

关 键 词：肿瘤 疼痛 基因治疗 

分 类 号：R614[医药卫生—麻醉学]