新生期疼痛对儿童痛觉敏感性的远期影响及其相关机制  

Long-term Impacts and Related Mechanisms of Neonate Pain in Neonatal Period on Pain Sensitization

作　　者：黄意坚[1] 吴斌[1] 

机构地区：[1]福建医科大学附属第一医院儿科,福州350005

出　　处：《医学综述》2010年第10期1519-1522,共4页Medical Recapitulate

基　　金：福建医科大学教授学术发展基金(JS08011)

摘　　要：新生期是儿童疼痛功能及其通路发育的关键时期。新生期接受任何伤害性刺激均影响个体疼痛功能及其通路的发育,进而影响到痛觉敏感性,而且,这种影响可持续至成年后。业已证实,新生期炎性刺激、机械刺激、结直肠扩张、神经损伤等均可造成儿童痛觉敏感性增高;其相关机制可能与新生期疼痛刺激后神经解剖、神经发育及神经递质改变有关。Neonatal period is a crucial stage for development of pain function and pain path of children.During the period,any noxious insult will affect their development,thereby affect their pain sensitization,and the impact will continue until adulthood.It has been proved that any kinds of noxious insult,such as inflammatory insults,mechanical insults,colonic irritation,physical nerve damage wil1 cause pain hypersensitivity.Its mechanisms maybe are related to the change of neurotomia,neural development and neuro-transmitters.

关 键 词：新生期 疼痛 远期影响 机制 

分 类 号：R246.4[医药卫生—针灸推拿学]