大剂量多巴酚丁胺二维超声心动图诊断冠心病的临床应用  

The Value of Dobutamine Stress Echocardiography in Diagnosis of Coronary Artery Disease

作　　者：李天亮[1,2] 康春松[1,2] 刘望彭[1,2] 冀瑞平 杨永生[1,2] 吕吉元 李学文[1,2] 王雄 李保[1,2] 

机构地区：[1]山西医科大学第一医院彩超室 [2]山西省心血管病研究所导管室

出　　处：《中国超声医学杂志》1999年第3期195-197,共3页Chinese Journal of Ultrasound in Medicine

基　　金：山西省科委攻关项目科研基金

摘　　要：目的：研究大剂量多巴酚丁胺二维超声心动图（ＤＳＥ）诊断冠心病的价值。方法：经冠状动脉造影证实的受试者３９例，其中冠心病２４例，正常对照１５例。多巴酚丁胺（ＤＢＡ）每隔３分钟以剂量递增的方式持续静注（５～４０μｇ／ｋｇ／ｍｉｎ），同时应用二维超声心动图重点观察室壁运动的变化，计算室壁运动得分指数（ＷＭＳＩ）。结果：用药后心率、收缩压、心率与收缩压的乘积（ＲＰＰ）均明显增高；冠心病组ＷＭＳＩ明显增加（Ｐ＜０．０１）。ＤＳＥ诊断冠心病的总敏感性７９％，特异性９３％，准确性８４％；诊断单支、双支及三支病变的敏感性分别为７６％、８０％、１００％。所有受试者均无严重的不良反应发生。结论：大剂量ＤＳＥ诊断冠心病安全、可靠，具有重要的临床实用价值。ABSTRACT Objective:To evaluate the effect of dobutamine str ess echocardiography test(DSE)on detection of myocardial ischemia. Methods:24 cases with coronary artery disease(CAD)and 15 subject s without CAD were studied.Dobutamine(DBA)was administered intravenusly (5,10,20 ,30,40 μg/kg/min). Results:After DBA infusion the heart rate(HR),the rate－pressuse pro duct(RPP)and the wall motion score indexes(WMSI)all increased in CAD patients.Th e ov erall sensitivity and the specificity of DSE for dctection of CAD were 79% and 9 3% respectivily.Its sensitivity for detection of 1,2,and 3vessels CAD were 76% ,80%,and 100% respectively.There was no severe adverse effect. Conclusion:DSE has important value for clinical application. KEY WORDS Echocardiography Dobutamine Coronary artery disease

关 键 词：超心动图 多巴酚丁胺 冠心病 诊断 

分 类 号：R541.404[医药卫生—心血管疾病] R540.45[医药卫生—内科学]