肺结核患者外周血CD4^+CD25^+调节性T细胞的检测及意义  

CD4^+CD25^+ regulatory T cell in peripheral blood of patients with pulmonary tuberculosis: Its detection and clinical significance

作　　者：柳红梅[1] 

机构地区：[1]浙江省绍兴市第六人民医院,浙江绍兴312000

出　　处：《上海预防医学》2010年第5期232-233,共2页Shanghai Journal of Preventive Medicine

摘　　要：[目的]通过对肺结核患者外周血中CD4+CD25+调节性T细胞的分析,探讨其在肺结核患者中的临床意义。[方法]采用流式细胞技术多色荧光分析法,测定84例肺结核患者及29例健康体检者外周血中CD4+CD25+调节性T细胞水平,观察肺结核患者与健康对照者之间、各型肺结核之间及结核杆菌阳性与阴性者之间的差别。[结果]肺结核患者CD4+CD25+所占比例为(10.81±2.65)%,与健康对照组差异有统计学意义(P<0.05);各型结核之间、抗酸杆菌阳性与阴性之间的差异有统计学意义(P<0.05);初治肺结核与复治肺结核也有一定的差异,但无统计学意义(P>0.05)。[结论]CD4+CD25+调节性T细胞可作为判断肺结核患者免疫功能的指标,它对肺结核患者的免疫状态、指导用药、疗效观察有一定的临床意义。[Objective] To analyze CD4＋CD25＋ regulatory T cell（Treg） in the peripheral blood of patients with pulmonary tuberculosis and explore its clinical significance. [Methods] A series of 84 pulmonary tuberculosis patients were detected by flow cytometry with multicolor fluorescence technology for CD4＋CD25＋ regulator T cell,with 29 healthy persons as control group.The differences were analyzed between types of pulmonary tuberculosis,bacteriologically positive and negative,initial treatment and retreatment. [Results] The percentage of CD4＋CD25＋ regulator T cell of pulmonary tuberculosis patients（10.81±2.65） was significantly higher than that of controls（P0.05）.The difference between bacterially positive and negative and between types was statistically significant（P0.05）.The difference between initial treatment and retreatment was certain but not significant（P0.05）. [Conclusion] CD4＋CD25＋ regulator T cell can be used as indicator of the immune function in pulmonary tuberculosis patients.It is of clinical significance for the observation of immune status,medication and curative effect on pulmonary tuberculosis patients.

关 键 词：肺结核 调节性T淋巴细胞 CD4+CD25+T细胞 

分 类 号：R521[医药卫生—内科学]