自制靶向脂质微泡与普通脂质微泡超声显影的对比实验研究  

Comparison of Self-made Targeted Liposome Microbubbles and General Lipid Microbubbles in Ultrasound Contrast Imaging

作　　者：余进洪[1] 王志刚[1] 李奥[1] 李雷雷[2] 冉海涛[1] 张亚萍[1] 

机构地区：[1]重庆医科大学超声影像学研究所重庆医科大学附属第二医院超声科,重庆市400010 [2]重庆医科大学妇幼与儿童少年卫生学教研室

出　　处：《中国超声医学杂志》2010年第5期385-388,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家863计划(No.2006AA02Z4F0);国家自然科学基金面上项目(No.30770566);国家自然科学基金面上项目(No.30770565)

摘　　要：目的探讨自制的靶向脂质微泡超声造影剂在正常兔肝脏与VX2兔肿瘤模型的超声成像特点,对比研究其与普通脂质做泡超声造影剂超声成像的异同。方法分别从正常兔及VX2肿瘤兔耳缘静脉团注普通脂质微泡超声造影剂与自制靶向脂质微泡超声造影剂,使用飞利浦iU22超声诊断仪的造影模式,实时监控2种不同造影剂各自的超声显影特点。DFY定量分析诊断仪分析图像的达峰时间、峰值回声强度、清除时间并对各组参数进行比较。结果在正常兔肝实质,普通脂质微泡超声造影剂(MB)达峰时间明显早于自制的靶向脂质微泡超声造影剂(MB’)达峰时间,峰值回声强度前者高于后者,清除时间前者显著短于后者。在VX2肿瘤区,MB达峰时间明显早于MB’,峰值回声强度前者明显高于后者,清除时间前者显著短于后者。结论自制靶向脂质微泡超声造影剂有其自身独特的超声显像过程和特点,呈"负向显影"模式。Objective To investigate the ultrasound imaging characteristics of the self-made lipid microbubbles targeted ultrasound contrast agents in normal rabbit liver and VX2 rabbit tumor model, as well as its similarities and differences. Methods Inject common lipid bolus microbubble ultrasound contrast agent and self-made lipid microbub- bles targeted ultrasound contrast agents into rabbit ear vein. Use Philips iU22 ultrasound imaging diagnostic mode, realtime fo monitor two different ultrasound contrast agent imaging characteristics. Analyze the peak time, peak echo intensity and clear time with DFY. The parameters of each group were compared. Results In the normal rabbit liver parenchyma, normal lipid ultrasound contrast agent （MB） time to peak was significantly earlier than the targeted selfmade lipid ultrasound contrast agent microbubbles （MB ） . Peak intensity of the former high-echo was higher than that of the latter. Removal time of the former was significantly shorter than that of the latter. In the VX2 tumor, MB peak time was significantly earlier than that of the MB . The peak echo intensity of the former was significantly higher than that of the latter. Removal time of the former was significantly shorter than that of the latter. Conclusions self-made lipid mierobubbles targeted ultrasound contrast agents have their own unique processes and characteristics in ultrasound imaging, which was ＂negative image＂ mode.

关 键 词：靶向 脂质微泡 超声造影 回声强度 

分 类 号：R943[医药卫生—药剂学]