Th1/Th2型细胞因子失衡与Graves病相关性研究  

Relationship between the Th1/Th2 cytokines imbalance and Graves diseases

作　　者：张金华[1] 冯玉欣[2] 赵艳艳[1] 刘惠萍[1] 

机构地区：[1]山东省潍坊医学院,261042 [2]山东省潍坊市人民医院内分泌科,261041

出　　处：《临床合理用药杂志》2010年第9期39-40,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨IL-6和TNF-α在Graves病(GD)发病中的作用。方法检测100例GD患者和40例年龄、性别相匹配的健康对照者血清IL-6、TNF-α水平,并与相关抗体进行相关性分析。结果观察组TNF-α、IL-6水平均显著高于对照组,差异有统计学意义(P<0.05);且TNF-α与血清甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)呈正相关。结论 GD一般呈Th2型细胞因子优势表达,体液免疫起主导作用。Objective To explore the role of IL-6 and TNF-α in Graves diseases（GD）pathogenesis.Methods The leves of TNF-α、IL-6 were examined in 100 Graves＇ disease and 40 healthy control subjects that age and sex matched and with relevant antibody correlation analysis. Results The levels of TNF-α and IL-6 in patients with GD were significantly higher than those in control groups（P 0. 01）,and the level of TNF-α were positively associated with TGAb and TPOAb（P 0. 05）. Conclusion GD is predominantly expressed Th2 cytokines,humoral immunity plays a dominant role.

关 键 词：细胞免疫 GRAVES病 细胞因子 

分 类 号：R581.1[医药卫生—内分泌]