巨噬细胞移动抑制因子与冠状动脉病变的关系  

Plasma macrophage migration inhibitory factor concentration and coronary lesions

作　　者：杨丽霞[1] 苗贵华[1] 齐峰[1] 王先梅[1] 石燕昆[1] 吕晋琳[1] 李明秋[1] 

机构地区：[1]成都军区昆明总医院心血管内科,云南昆明市650032

出　　处：《中华老年多器官疾病杂志》2010年第1期48-50,55,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的探讨冠心病患者血浆巨噬细胞移动抑制因子(MIF)水平与冠状动脉粥样硬化病变的关系。方法根据选择性冠状动脉造影结果将142例患者分为冠心病组和对照组。冠心病组根据临床诊断分为稳定型心绞痛(SAP)和急性冠脉综合征(ACS)组;根据冠状动脉病变范围将冠心病组分为单支病变、双支病变和三支病变组。血浆MIF浓度通过ELISA法测定。结果冠心病组MIF水平明显高于对照组〔(14.97±4.11)vs(9.07±1.28)μg/L〕,ACS组MIF浓度又明显高于SAP组〔(16.66±3.56)vs(11.01±2.12)μg/L〕。随冠状动脉病变范围的增加,MIF浓度逐渐升高,各组间差异有显著统计学意义。结论MIF增高与冠状动脉粥样硬化发生显著相关,其可以做为预测冠状动脉粥样硬化病变情况的一个指标,与冠状动脉粥样硬化斑块不稳定关系更密切。Objective To investigate the relationship between the plasma macrophage migration inhibitory factor （MIF） concentration and coronary arteriosclerosis lesions in patients with coronary heart diseases （CHD）. Methods Totally 142 patients were divided into CHD group and control group according to the result of the coronary angiography （CAG）. CHD group was further divided into stable angina pectoris （SAP） group and acute coronary syndrome （ACS） group according to the clinical diagnosis; and divided into one-vessel,two-vessel,three-vessel group according to the extent of coronary lesion. The plasma MIF concentration was measured by ELISA. Results The plasma MIF concentration was significantly higher in CHD group than in control group〔（14.97±4.11） vs （9.07±1.28） μg/L〕,and in ACS group than in SAP group〔（16.66±3.56） vs （11.01±2.12） μg/L〕. The plasma MIF concentration increased gradually with the increase of extent of coronary lesions. Conclusions The increase of plasma MIF concentration is significantly associated with development of coronary arteriosclerosis. MIF can be a reliable predictive index for coronary arteriosclerosis progression. MIF has a high association with unstable plaques in coronary arteriosclerosis.

关 键 词：巨噬细胞移动抑制因子 冠心病 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]