超声学联合血清AFP和HCG检测在产前筛查中的应用  

Sonography Combined with Detection of AFP and β-HCG in Prenatal Screening

作　　者：郑建华[1] 陈爱灼[1] 许菁菁[1] 陈薇[1] 苏仙练[1] 

机构地区：[1]莆田学院附属医院超声科,莆田351100

出　　处：《福建医科大学学报》2010年第2期140-142,共3页Journal of Fujian Medical University

摘　　要：目的探讨颈项透明层厚度（NT）超声联合血清甲胎蛋白（AFP）和β-人绒毛膜促性腺激素（HCG）检测在产前筛查中的应用。方法收集产前健康体检的孕妇702例,于孕10-14周,超声测量孕妇胎儿NT;于孕10-21周,ELISA法检测孕妇血清AFP和HCG水平,并随访孕妇妊娠结局及胎儿异常情况。结果 702例中,超声检出NT高危25例,其中妊娠结局显示胎儿异常8例（32.0%）;血清学高危10例,其中妊娠结局显示胎儿异常6例（60.0%）;联合筛查高危5例,其中妊娠结局显示胎儿异常4例（80.0%）。结论 NT超声联合血清AFP和HCG检测应用于产前筛查可提高胎儿异常的阳性检出率,可作为产前筛查的一项有效手段。Objective To evaluate the application of sonography combined with serology in prenatal screening.Methods Nuchal translucency thickness（NT）of embryos at 10-14 weeks in 702 pregnant women were scanned by sonography.AFP and β-HCG in the blood of these women at 10~21 weeks of pregnancy were detected by ELISA.The outcomes of pregnancy and abnormal fetuses were followed up.Results Of the 702 cases,8 of the 25 high-risk cases by sonography（NT≥3 mm） turned out to be abnormal pregnancies,and the positive rate was 32.0%;6 of the 10 high-risk cases by serology were abnormal pregnancies,and the positive rate was 60.0%;4 of the 5 high-risk cases by sonography and serology were abnormal,positive rate at 80.0%.Conclusions The combined application of sonography with serology is an effective method in prenatal screening and is superior to the application of sonography or serology alone.

关 键 词：甲胎蛋白类 绒毛膜促性腺激素 β亚单位 人 超声检查 产前 颈部透明带厚度检查 妊娠结局 

分 类 号：R714.5[医药卫生—妇产科学] R347.512[医药卫生—临床医学]