儿童哮喘相关因素Logistic回归分析  

The Logistic regression analysis on related factors of asthmatic children

作　　者：安淑华[1] 王艳艳[1] 宋庆[2] 史玲艾[1] 赵清娟[1] 李金英[1] 郑博娟[1] 王宁[1] 王萌萌 

机构地区：[1]河北省儿童医院呼吸科,河北石家庄050031 [2]航天中心医院儿科,北京100049

出　　处：《临床儿科杂志》2010年第5期455-458,共4页Journal of Clinical Pediatrics

基　　金：河北省科技支撑计划项目(No.08276101D-76)

摘　　要：目的调查儿童哮喘发病相关因素,以便临床采取有效干预措施,降低其发病率和复发率。方法收集2007年1月-2009年3月河北省儿童医院呼吸科诊治的哮喘患儿及非哮喘患儿共1 000例,按年龄、性别、居住地区对两组患儿进行1∶1配对,形成500个匹配组,以问卷形式调查,对入选的病例从生后首次喘息开始追溯,查找哮喘发病相关因素。结果研究调查33个因素,经条件Logistic回归分析,去除8个因素,最终进入回归方程的有25个因素,其中高危因素6个、中危因素2个、低危因素12个、保护因素5个。结论遗传因素与哮喘密切相关,特应性体质是儿童哮喘的危险因素,频发的呼吸道感染可促使哮喘发展为持续性,室内外环境不良与哮喘相关;母孕期合理饮食,儿童营养均衡可减少患儿哮喘的发病。Objective To study valid clinical treatments and methods of reducing the morbidity and relapse rate of asthma,related factors of asthma in children were investigated.Methods Five hundred asthmatic children were enrolled from pediatric patients hospitalized in the Department of Pulmonology of Hebei Children＇s Hospital from January 2007 to March 2009.Asthmatic patients were 1 ∶ 1 matched with nonasthmatic children of same age,sex and region,forming 500 paired groups.Questionnaire was used to find related factors.Results Total 33 factors were investigated and analyzed by Logistic regression analysis.Eight factors were excluded and 25 factors were included in the end.There were 6 high risk factors,2 middle level risk factors,12 low risk factors and 5 protective factors.The high risk factors included familial asthma,eczema and the others.Middle level risk factors included the parents＇ and patients＇ history of allergy and asthma.Low risk factors included the history of urticaria,passive smoking etc.Protective factors included eating fish and apples frequently during pregnancy,breastfeeding,timely Bacillus Calmette-Guerin（BCG） vaccination etc.Conclusions Genetic factors were closely related to the development of asthma in children.The atopic constitution was a risk factor of asthma.Frequent respiratory tract infections promoted the persistent asthma.Air pollution of both indoor and outdoor environment was associated with asthma.Reasonable diet in pregnancy and balanced nutrition of children＇s diet would reduce the incidence of asthma in children.

关 键 词：哮喘 儿童 危险因素 保护因素 病例对照研究 

分 类 号：R725.6[医药卫生—儿科]