丹参酮Ⅱ_A磺酸钠注射液的安全性评价  

Safety of sodium tanshinone Ⅱ_A sulfonate injection

作　　者：曹晓梅[1] 陈小铭[1] 孙维林[1] 

机构地区：[1]南京军区南京总医院药理科,南京医学硕士210002

出　　处：《医学研究生学报》2010年第5期474-476,共3页Journal of Medical Postgraduates

基　　金：国家自然科学基金(30472055)

摘　　要：目的丹参酮ⅡA磺酸钠临床用于抗肿瘤、治疗心脑血管疾病以及抗菌消炎等,文中评价丹参酮ⅡA磺酸钠注射液的安全性。方法以等渗氯化钠溶液为阴性对照进行体外溶血试验,兔耳缘静脉血管刺激试验,肌肉注射刺激试验和豚鼠全身过敏性试验。结果丹参酮ⅡA磺酸钠注射液(临床使用浓度1mg/m l)3 h内不引起溶血或红细胞凝集反应。丹参酮ⅡA磺酸钠注射液(4mg/kg)对兔耳缘静脉和股四头肌无刺激作用,不引起豚鼠全身过敏反应。结论丹参酮ⅡA磺酸钠注射液在本实验条件下安全性较好,可供临床注射使用。Objective Sodium tanshinone ⅡA sulfonate（STS） is clinically used in the treatment of cancer,cardiovascular diseases and bacterial infections.The purpose of this study was to evaluate the safety of STS injection.Methods We conducted the hemolytic test in vitro,the stimulating test in the auricular veins and muscles of rabbits,and the allergic test in guinea pigs,with normal saline used as the control.Results STS injection at the concentration of 1 mg/ml induced no hemolysis or reaction in erythrocyte agglutination at 3 hours,nor stimulus to the auricular veins and muscles of the rabbits at 4 mg/kg,nor systemic anaphylaxis in the guinea pigs.Conclusion Under experimental conditions,STS injection is safe for clinical use.

关 键 词：丹参酮ⅡA磺酸钠注射液 溶血试验 过敏反应 

分 类 号：R972[医药卫生—药品]