高龄2型糖尿病患者血清超敏C反应蛋白及细胞因子检测的临床意义  

Clinical significance of determination of serum high sensitive C-reactive protein and cytokine levels in the very elderly with type 2 diabetes mellitus

作　　者：朱小蔚[1] 张兴虎[1] 万文辉[1] 刘永华[1] 钱晓明[1] 

机构地区：[1]南京军区南京总医院干部病区,南京210002

出　　处：《医学研究生学报》2010年第5期492-494,共3页Journal of Medical Postgraduates

基　　金：南京军区卫生部课题(08MA089)

摘　　要：目的近来研究显示,炎症因子在2型糖尿病(type 2 diabetes mellitus,T2DM)发病机制中起媒介作用。文中主要探讨高龄(≥80岁)T2DM患者血清超敏C反应蛋白(high sensitive C-reactive protein,HsCRP)及细胞因子水平变化。方法选取高龄糖尿病患者45例(糖尿病组)和高龄健康人36例(对照组)分别检测血清HsCRP、白细胞介素(interleukin,IL)-2、IL-6及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平。经彩色多普勒检查2组患者颈动脉内膜-中膜增厚(intima-media thickness,IMT)、斑块形成来评判动脉粥样硬化(atherosclerosis,AS)的程度。结果高龄2型糖尿病组的血清HsCRP、IL-6、TNF-α水平明显高于对照组(P<0.05),而前组的IL-2水平明显低于后组(P<0.05)。与对照组相比,糖尿病组AS的程度更严重(P<0.05)。结论血清HsCRP、IL-6、TNF-α水平的升高以及IL-2水平的降低可能参与高龄2型糖尿病的发病机理,并与糖尿病患者AS的发生及其严重程度相关。Objective Recent studies have suggested that inflammatory factors were the intermediate in the pathogenesy of type 2 diabetes mellitus（T2DM）.Our research is to investigate the changes of serum hypersensitive C-reactive protein（HsCRP） and cytokine levels in the very elderly with T2MD.Methods The serum levels of HsCRP,IL-2,IL-6,TNF-αwere observed in 45 very elderly patients with T2MD,and compared with those in 36 very elderly controls.Carotid artery intima-media thickness（IMT） and atherosclerotic plaque were also examined in order to evaluate the degree of atherosclerosis（AS）.Results The serum levels of HsCRP,IL-6 and TNF-αwere higher,the serum IL-2 level was lower,and the degree of AS was severer in the very elderly patients with T2MD than those in the very elderly controls.Conclusion The increased levels of HsCRP,IL-6,TNF-α and the decrease level of the IL-2,may participate in the pathogenesis of the very elderly with T2MD,and may have relevance to the development and the severity of AS in these patients.

关 键 词：高龄 2型糖尿病 细胞因子 超敏C反应蛋白 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]