5-氨基酮戊酸-光动力疗法治疗尖锐湿疣疗效观察  

5-Aminolevulinic Acid-Photodynamic Therapy for Condylomata Acuminata

作　　者：秦晓蕾[1] 杨帆[1] 冯丹珍 黄海鹏[1] 陈知英[1] 

机构地区：[1]广东省深圳市慢性病防治中心皮肤性病科,深圳市518020

出　　处：《中国激光医学杂志》2010年第2期106-109,共4页Chinese Journal of Laser Medicine & Surgery

摘　　要：目的观察5-氨基酮戊酸-光动力疗法治疗尖锐湿疣的疗效。方法尖锐湿疣患者50例,病变主要见于尿道口,其次是宫颈口、包皮、大阴唇和肛周。病变及其周围先涂以20%的5-氨基酮戊酸凡士林霜,然后以波长632.8nm,功率100mW,光斑直径2～4cm,能量密度100mJ/cm2的He-Ne激光照射。结果尿道口处病变痊愈率为97.2%,复发率为2.8%;宫颈口处病变痊愈率为75%,复发率为25%;包皮处病变痊愈率为75%,复发率为25%;肛周治愈率为40%,复发率为60%。结论5-氨基酮戊酸-光动力疗法治疗尖锐湿疣疗效确切,复发率较低,其疗效与病变部位、治疗次数相关。Objective To evaluate 5-aminolevulinic acid-photodynamic therapy （ALA-PDT） for condyomata acuminata （CA）. Methods Fifty patients with CA were treated.The lesions were mainly distributed in urethral orifice, and then in cervix, prepuce, greater lips of pudendum and perianum. 20% 5-Aminolevulinic acid cosmolin cream was spreaded on the lesions and surrounding skin. The laser with wavelength of 632.8 nm, power of 100 mW and fluence of 100 mJ/cm2 was used to irradiate the treated area with diameter 2-4 cm.Results The complete remission rate was 97.2% and the recurrence rate was 2.8% in the patients with urethral CA vs 75% and 25% of the patients with cervical and preputial CA. The complete remission rate was the lowest （only 40%） and the recurrence rate was the highest （60%） in the patients with perianal CA. Conclusions The effect of ALA-PDT for CA is definite and the recurrence rate is lower. The effect is related with the lesion locations and treatment sessions.

关 键 词：尖锐湿疣 5-氨基酮戊酸 光动力疗法 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]