局部三联疗法治疗黄褐斑临床疗效观察  

Observation of Clinical Effect of Local Triple Therapy in the Treatment of Chloasma

作　　者：匡薇薇[1] 张瑞丽[1] 任虹[1] 

机构地区：[1]江苏省连云港市第一人民医院,222000

出　　处：《职业与健康》2010年第10期1189-1190,共2页Occupation and Health

摘　　要：目的观察局部三联疗法(2%氢醌乳膏、0.1%全反式维A酸乳膏、0.1%丁酸氢化可的松软膏)治疗黄褐斑的临床疗效及安全性。方法采用随机、双盲、对照方法。将120例黄褐斑患者随机分为3组,A组40例,采用2%氢醌乳膏、0.1%全反式维A酸乳膏联合0.1%丁酸氢化可的松软膏治疗;B组40例,单用2%氢醌乳膏治疗;C组40例,单用0.1%全反式维A酸乳膏治疗。各组均连续治疗12周并判断疗效及不良反应。结果A组治疗黄褐斑疗效优于B组、C组,疗效差别有统计学意义(P<0.05),且不良反应少。结论局部三联疗法治疗黄褐斑疗效好,安全性高,是治疗黄褐斑的理想方法之一。[Objective]To observe the clinical efficacy and safety of the triple therapy （2% hydroquinone cream,0.1% all-trans retinoic acid cream and 0.1% hydrocortisone butyrate ointment） in the treatment of chloasma.[Methods]A randomized,double-blind and controlled method was adopted.120 patients with chloasma were randomly divided into three groups.Group A （40 cases） was treated with the combination of 2% hydroquinone cream,0.1% all-trans retinoic acid cream and 0.1% hydrocortisone butyrate ointment,group B （40 cases） was given only 2% hydroquinone cream,and group C （40 cases） received single 0.1% all-trans retinoic acid cream.All patients were treated for 12 weeks continuously,and the clinical efficacy and adverse reaction were observed and analyzed.[Results]The clinical efficacy of group A was better than that of group B and group C,the difference was significant （P0.05）,and adverse reactions of group A were mild.[Conclusion]The local triple therapy has the advantages of good efficacy and high safety,and it is an ideal therapy for chloasma.

关 键 词：三联疗法 黄褐斑 

分 类 号：R758.4[医药卫生—皮肤病学与性病学]