雌二醇对大鼠小肠黏膜IgA^+细胞的影响  

Effect of estradiol on IgA^+ cells in small intestine mucosa of rat

作　　者：闫金坤[1,2] 杨文星 李靖华 陈耀星[1] 

机构地区：[1]中国农业大学动物医学院,北京100094 [2]河北工程大学农学院,河北邯郸056038 [3]馆陶县畜牧水产局,河北馆陶057750 [4]任丘市畜牧水产局,河北任丘062550

出　　处：《黑龙江畜牧兽医》2010年第1期5-6,共2页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(3047124730671514)

摘　　要：为了研究雌二醇对大鼠小肠黏膜IgA+细胞的影响,试验采用免疫组化LSAB法染色,对不同剂量雌二醇处理的各组Wistar雌性大鼠小肠黏膜IgA+细胞的数量进行了统计。结果表明:与对照组相比,卵巢摘除组大鼠小肠黏膜IgA+细胞的数量显著减少;与卵巢摘除组相比,补充适量的雌二醇后,小肠黏膜IgA+细胞的数量显著增多。结果说明卵巢摘除使大鼠小肠黏膜免疫功能降低,补充适量雌二醇后这种情况可以得到改善。To explore the effect of estradiol on IgA^＋ cells in small intestine mueosa of the rat, immunohistoehemistry was used in the experiment, and the amount of IgA^＋ cells of female Wistar rats that had been given different dosage of estradiol was calculated. The result showed that com- pared with control group, the IgA^＋ cell number of the rats whose ovary had been removed has increased remarkably while compared with OVX group, the IgA^＋ cell number of the rats that had been given proper dosage of estradiol has increased remarkably. A conclusion, therefore, has been reached that removing ovary can reduce the immunity of small intestine mucosa in rats while giving dosage of estradiol can change the effect for better.

关 键 词：雌二醇 IgA+细胞 小肠 

分 类 号：S865.12[农业科学—野生动物驯养]