Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence  

作　　者：Bin LU Mu LI Yuan-yuan HOU Jie CHEN Zhi-qiang CHI Jing-gen LIU 

机构地区：[1]State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

出　　处：《Acta Pharmacologica Sinica》2010年第4期387-392,共6页中国药理学报（英文版）

基　　金：AcknowledgementsThis study was supported by the National Basic Research Program grants from the Ministry of Science and Technology of China （No 2003CB515400 and No 2009CB522000）, the National Science Fund for Distinguished Young Scholars from the National Natural Science Foundation of China （No 30425002） and the Chinese Academy of Sciences （No KSCXI/YW/R/68）. We thank Aaron Ettenberg for helpful suggestions on runway behavior and Barry J Everitt for the heterogeneous chained schedule.

摘　　要：Aim： To evaluate the influence of an initial heroin experience under a modified two-chained training schedule on drug-seeking behavior after a long abstinence period. Methods： Rats were trained to respond for intravenous heroin （120 μg/kg） under a heterogeneous chained schedule of reinforcement using different responses in the first and second links of the chain. Animals received low-frequency drug administration training for four days and were then subjected to one month of abstinence in their home cages. Heroin-seeking behavior induced by re-exposure to the first chain associated context or discriminative stimuli was assessed after abstinence. Results： Almost all animals could acquire operant skills quickly under the two-chained schedule training for four days, as measured in first active response latency, travel speed and goal-box enter latency. Both first chain associated context and discriminative stimulus could reinstate heroin-seeking behavior after one month abstinence. Conclusion： These observations suggest that an early experience of drug use is sufficient to maintain heroin-seeking behavior even after a one month abstinence.Aim： To evaluate the influence of an initial heroin experience under a modified two-chained training schedule on drug-seeking behavior after a long abstinence period. Methods： Rats were trained to respond for intravenous heroin （120 μg/kg） under a heterogeneous chained schedule of reinforcement using different responses in the first and second links of the chain. Animals received low-frequency drug administration training for four days and were then subjected to one month of abstinence in their home cages. Heroin-seeking behavior induced by re-exposure to the first chain associated context or discriminative stimuli was assessed after abstinence. Results： Almost all animals could acquire operant skills quickly under the two-chained schedule training for four days, as measured in first active response latency, travel speed and goal-box enter latency. Both first chain associated context and discriminative stimulus could reinstate heroin-seeking behavior after one month abstinence. Conclusion： These observations suggest that an early experience of drug use is sufficient to maintain heroin-seeking behavior even after a one month abstinence.

关 键 词：heroin initial experience two-chained schedule ABSTINENCE reinstatement 

分 类 号：O4-09[理学—物理] R996[医药卫生—毒理学]