选择性血浆净化器对胆红素吸附的疗效观察  

Therapeutic effects of selective plasma purifier on bilirubin adsorption

作　　者：向德栋[1] 毛青[1] 王宇明[1] 王小红[1] 赵颂涛[1] 郑少琴[1] 张绪清[1] 陈耀凯[1] 陈嵩[1] 马巧玉[1] 李玲[1] 

机构地区：[1]第三军医大学西南医院全军感染病研究所,重庆400038

出　　处：《传染病信息》2010年第2期93-94,100,共3页Infectious Disease Information

基　　金：国家高技术研究发展计划(863计划)专题(2006AA02-A140)

摘　　要：目的观察选择性血浆净化器对胆红素吸附的疗效及安全性。方法选择慢性乙型肝炎重度、慢性重型乙型肝炎和药物性肝损害24例,在综合治疗基础上给予血浆灌流支持治疗,观察血浆灌流支持治疗前后肝功能、血常规、凝血三项、组织相容性评价及血气分析的变化情况,并记录不良反应的发生率。结果所有患者治疗后血清TBIL、DBIL、IBIL分别下降(105.49±33.10)、(55.63±24.22)、(49.83±26.79)μmol/L,经自身配对t检验,P均<0.05;治疗过程中患者耐受性好,无明显不良反应发生。结论选择性血浆净化器不仅有好的治疗效果,而且安全性好。Objective To evaluate the therapeutic effects and safety of selective plasma purifier on bilinlbin adsorption. Methods A total of 24 patients with advanced chronic hepatitis B （CHB）, severe CHB or drug-induced liver injury were treated with plasma perfusion based on a comprehensive treatment. The alterations in the parameters of liver function, routine blood, blood coagulation, histocompatibility evaluation and blood gas analysis were observed and compared before and after treatment, and the incidence rate of adverse reaction was recorded. Results After treatment, the levels of serum total bilirubin, direct bilirubin and indirect bilirubin of all the patients decreased by （105.49±33.10）, （55.63±24.22） and （49.83±26.79） μmol/L, respectively, and self- paired t test showed the differences were statistically significant compared to pretreatment levels （P〈0.05）. Good treatment tolerance was shown and no obvious adverse reactions were found during treatment. Conclusion Selective plasma purifier shows good therapeutic effects and good safety as well.

关 键 词：肝 人工 肝炎 乙型 慢性 血浆 灌注 胆红素 

分 类 号：R318.14[医药卫生—生物医学工程] R512.62[医药卫生—基础医学]