联合使用氨基葡聚糖和硫酸软骨素抗炎镇痛作用实验研究  

Anti-inflammatory and Analgesic Effects of Combined Application of Glucosamine and Chondroitin Sulfate

作　　者：杨春燕[1] 韩刚[2] 王锦程 原海忠[1] 董月[1] 翟冠钰[1] 范颖[1] 康英 

机构地区：[1]唐山市第二医院,唐山063000 [2]华北煤炭医学院药学系 [3]唐山容大药业有限公司

出　　处：《中国运动医学杂志》2010年第3期313-315,共3页Chinese Journal of Sports Medicine

摘　　要：目的:研究联合使用氨基葡聚糖和硫酸软骨素对大鼠和小鼠的抗炎镇痛效果及作用机制。方法:采用SD大鼠,于左后足趾中部皮下注射角叉菜胶建立足趾肿胀模型,对联合使用氨基葡聚糖和硫酸软骨素抗急性炎症疗效进行评价;将灭菌棉球植入大鼠两侧腹股沟皮下建立肉芽肿模型,进行抗慢性炎症疗效评价。采用ICR小鼠,腹腔注射0.6%醋酸溶液建立小鼠疼痛模型,对联合使用氨基葡聚糖和硫酸软骨素镇痛作用进行评价。结果:与正常对照组比较,联合使用氨基葡聚糖和硫酸软骨素可降低大鼠足趾肿胀度(P<0.05),联合使用氨基葡聚糖和硫酸软骨素可明显抑制大鼠肉芽肿(P<0.01),联合使用氨基葡聚糖和硫酸软骨素可明显抑制醋酸致小鼠扭体次数(P<0.05)。结论:联合使用氨基葡聚糖和硫酸软骨素,具有抗急性炎症及慢性炎症作用;可抑制醋酸致小鼠扭体反应次数,具有镇痛作用。Objective To investigate the anti-inflammatory and analgesic effects of combined application ofglucosamine（GS）and chondroitin sulfate（CS）. Methods The acute and chronic anti-inflammatory effects of combined application of GS and CS were observed respectively through carrageen-induced paw edema and cotton-inducedinguinal granuloma of rats. The analgesic effect of combined application of GS and CS was investigated by the mousepain model induced by 0.6% acetic acid. Results As compared with the control group,the degree of paw edema and the weight of granuloma in combined application of GS and CS group were significantly reduced（P〈0.05 and P〈0.01,respectively）;and the writhing number of mice decreased significantly（P〈0.05）. Conclusion Combined application of glucosamine and chondroitin sulfate demonstrates obviously anti-inflammatory and analgesic effects.

关 键 词：氨基葡聚糖 硫酸软骨素 抗炎 镇痛 

分 类 号：R96[医药卫生—药理学]