外用钙调磷酸酶抑制剂治疗面部脂溢性皮炎  

Topical calcineurin inhibitors in the treatment of facial seborrheic dermatitis

作　　者：赵珏敏[1] 项蕾红[1] 

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040

出　　处：《国际皮肤性病学杂志》2010年第3期140-142,共3页International Journal of Dermatology and Venereology

摘　　要：脂溢性皮炎是一种常见的炎症性皮肤病,以红斑、鳞屑、不同程度瘙痒为特征,好发于皮脂腺分泌旺盛部位,给患者的生活、工作带来影响.由于其具有慢性、复发性的特点,更需要一种安全有效的、可以长期使用的治疗手段.过去,脂溢性皮炎的治疗主要为抗真菌药、角质剥脱剂和糖皮质激素.近年,外用免疫调节剂成为慢性炎症性皮肤病的新型治疗方法.多项脂溢性皮炎的临床研究表明,钙调磷酸酶抑制剂,如他克莫司、吡美莫司治疗面部脂溢性皮炎安全有效.Seborrheic dermatitis is a common inflammatory skin condition characterized by erythema,scaling and pruritus with a predilection for areas rich in sebaceous glands. It affects patients＇ quality of life to an extent. Since it is a chronic and recurrent disease, there is a strong need for safe alternatives for its longterm management. In the past, antifungals, topical corticosteroids and keratolytics were the mainstay of its therapy. Now topical calcineurin inhibitors provide a safe alternative treatment for it. It has been demonstrated that such calcineurin inhibitors as pimecrolimus and tacrolimus are effective and safe in the treatment of facialseborrheic dermatitis.

关 键 词：皮炎 脂溢性 他克莫司 吡美莫司 

分 类 号：R758.7[医药卫生—皮肤病学与性病学]