针药结合增效机制研究的新思路探讨  

Discussion on the Novel Clues for Studying the Underlying Mechanisms of Acupuncture-induced Potentiation of the Curative Effect of Medicines

作　　者：崔晶晶[1] 高俊虹[2] 王玉敏[1] 马淑骅[1] 胡剑江[1] 马琰岩[1] 喻晓春[1] 

机构地区：[1]中国中医科学院医学实验中心,北京100700 [2]中国中医科学院针灸研究所,北京100700

出　　处：《针刺研究》2010年第2期146-150,共5页Acupuncture Research

基　　金：北京市自然科学基金资助项目(7072053);国家自然科学基金资助项目(30873295);科技部"973"计划专项课题(2006CB504506)

摘　　要：临床实践证明,包括穴位注射在内的针灸与药物的结合应用可以产生更好的疗效。而针药结合增效作用的机制迄今不甚清楚。本文结合既往的研究,提出针灸可能通过影响药物在体内的吸收、分布和代谢过程等,从而改变血药浓度、靶器官药物浓度或药物的生物利用度,也可通过影响靶器官细胞上特异性受体及其信号转导路径而改变细胞对药物的反应性或敏感性,最终提高药物的疗效。上述思路将可能为针药结合增效机制的研究提供新的线索。Acupuncture combined with drugs has been widely used in the treatment of various clinical conditions and can produce a stronger or more beneficial curative effect than either separate acupuncture or chemical drug does. However, the mechanisms underlying the additive or synergetic effects of acupuncture plus drugs are not well understood so far. Based on careful review and analysis of the literature accumulated, the authors proposed several aspects possibly involving the additive or synergetic effects produced by acupuncture plus drugs. For instance, acupuncture stimulation at acupoints may influence the drug concentration in blood and/or in target organ and the bioavailability of the drug via modulating the drug absorption, distribution and metabolism in the body. In addition, the curative effect of drug may also be strengthened by acupuncture stimulation via altering the signaling pathways of the targeted specific receptors and via potentiating the resultant responsiveness or sensitivity of the cells in the target organ in responding to the drugs administered. The ideas mentioned above may raise the novel clues for further studying the mechanisms underlying acupuncture-produced increase of the curative effects of medicines.

关 键 词：针药结合 增效机制 新思路 

分 类 号：R245.31[医药卫生—针灸推拿学]