痰湿体质高血压病患者脂联素异常与脂联素基因多态性的相关性研究  

Correlation Study on Serum Adiponectin Abnormity with Adiponectin Gene Polymorphisms in Hypertensive Patients of Phlegm-dampness Constitution

作　　者：钱岳晟[1] 张怡[1] 周晓鸥[1] 张伟忠[1] 高平进[1] 朱鼎良[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院,上海市高血压研究所,上海市血管生物学重点实验室,上海200025

出　　处：《中国中西医结合杂志》2010年第5期454-457,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市自然基金资助项目(No.08ZR1415000);上海交通大学医学院科技基金资助项目(No.2007XJ039)

摘　　要：目的探讨痰湿体质与非痰湿体质高血压病患者脂联素(adiponectin,APN)水平的差异,以及这种差异与APN基因多态性的关联。方法将250例高血压病患者(痰湿组137例,非痰湿组113例)进行血清APN检测,选择APN基因8个单核苷酸(single nucleotide polymorphism,SNP)位点进行相关性研究。结果痰湿组和非痰湿组血清APN水平分别为(5.07±0.35)μg/mL和(6.41±0.39)μg/mL,两组比较,差异有统计学意义(P=0.045);两组APN基因8个SNP位点的多态性分布差异无统计学意义(P>0.05);APN基因rs1063537(3224C/T)多态性位点痰湿组血清APN水平均明显低于非痰湿组,TT位点分别为(2.580±1.029)μg/mL、(6.011±0.945)μg/mL,CT位点分别为(5.113±0.968)μg/mL、(7.812±0.161)μg/mL,差异有统计学意义(P=0.017,P=0.021)。CC位点分别为(5.426±0.591)μg/mL、(6.130±0.668)μg/mL,差异无统计学意义(P>0.05)。结论痰湿体质高血压病患者血清APN水平明显低于非痰湿质高血压病患者,而且APN基因SNP3224的T基因携带者可能是APN异常的遗传特征。Objective To explore the difference of serum adiponectin （APN） level in hypertensive patients of phlegm-dampness constitution （PDC） and in those of non-PDC, as well as its association with APN gene polymorphisms. Methods Serum APN levels in 250 hypertensive patients （137 of PDC and 113 of non-PDC） were determined, and a correlation study was performed on 8 selected single nucleotide polymorphism （SNP） of APN gene. Results Significant differences of serum APN levels were observed between PDC and non-PDC patients （5.07±0.35 μg/mL vs 6.41±0.39 μg/mL, P=0.045）. No significant difference in polymorphism distribution of the 8 SNP sites of APN genes was found between patients of different constitutions （P0.05）. Serum APN level was significantly lower in PDC patients than in non-PDC patients in sites of APN gene rs1063537（3224C/T） polymorphism TT genotype （2.580±1.029 μg/mL vs 6.011±0.945 μg/mL, P= 0.017） and CT genotype （5.113±0.968 μg/mL vs 7.812±0.161 μg/mL, P=0.021）, while that of CC genotype was insignificant between the two constitutions （5.426±0.591 μg/mL vs 6.130±0.668 μg/mL）. Conclusion Serum APN level was significantly lower in hypertensive patients of PDC than in those of non-PDC. Moreover, the APN gene SNP3224 T allele carrier might be a hereditary feature of APN abnormity.

关 键 词：高血压病 脂联素 痰湿体质 基因多态性 

分 类 号：R259[医药卫生—中西医结合]