400mgI/ml含碘对比剂在双源CT冠状动脉成像中的初步应用研究  

Initial Experience on Application of 400mgl/ml Iodine Contrast Medium in DSCT Coronary Angiography

作　　者：孔令燕[1] 王怡宁[1] 张竹花[1] 宋兰[1] 金征宇[1] 王沄[1] 张晓娜[1] 赵文敏[1] 

机构地区：[1]北京协和医院放射科,北京100730

出　　处：《中国医学影像学杂志》2010年第3期236-241,共6页Chinese Journal of Medical Imaging

摘　　要：目的:评价碘浓度为400mgI/ml的含碘对比剂采用较低的给药速度和剂量,用于双源CT冠状动脉成像的血管增强程度及分支显示情况,对其是否能达到常规造影剂使用的同等效果进行探讨。材料和方法:40例临床怀疑冠心病的患者随机分为两组,分别采用400mgI/ml碘美普尔45ml,给药速度4ml/s(组1)或370mgI/ml碘普罗胺65ml,给药速度5ml/s(组2)的给药方案。所有患者采用双源CT进行扫描,比较两组冠状动脉的4个主要分支、升主动脉、降主动脉及肺动脉的增强值及其冠状动脉分支的显示率。结果:两组4个冠状动脉主要分支、升主动脉、降主动脉主要分支各段显示率未见明显差异(P>0.05),部分小分支显示率组2高于组1(P>0.05)。结论:碘浓度400mgI/ml含碘对比剂用于双源CT冠状动脉成像,采用较低的给药速度与剂量,能够达到常规造影剂使用的同等效果。Purpose To evaluate intracoronary attenuation and visibility of coronary arteries on dual-sauce computed tomography（DSCT） coronary angiography using contrast medium with concentration of 400mgI/ml,in lower injection rate and contrast medium volume;and to discuss whether this injection protocol could provide relevant enhancement in compare with conventional contrast medium.Material and Methods Forty patients with suspected coronary artery disease were randomized to 2 groups,received 45ml iomeprol 400 mgI/ml,with injection speed of 4ml/s（group 1）,or 65ml iopromide 370mgII/ml,with injection speed of 5ml/s（group 2）.All patients were given CT coronary angiography with DSCT.The attenuation of 4 main branches of coronary arteries,ascending aorta,descending aorta and pulmonary artery was measured.Mean attenuation and visibility of coronary arteries were compared between the 2 groups.Results No significant differences were found in the mean attenuation of 4 main branches of coronary arteries,the ascending aorta or descending aorta between 2 groups.The mean attenuation of the pulmonary artery of group 1 was greater（P0.05） than that of group 2.The visibility of the main branches of cronary arteries was similar in 2 groups（P0.05）,while the visibility of some small branches was higher in group2（P0.05）.Conclusion DSCT coronary angiography using contrast with 400mgI/ml concentration of iodine,in injection rate and contrast medium volume,is able to obtain relevant enhancement in compare with conventional contrast medium.

关 键 词：冠状动脉疾病 体层摄影术 X线计算机 冠状血管造影术 造影剂 

分 类 号：R541.404.54[医药卫生—心血管疾病]