梅毒患者与HLA-DRB1等位基因相关性研究  

Association between HLA- DRB1 alleles and syphilis patients

作　　者：蒋红伟[1] 田洪青[1] 李中伟[1] 李娜[1] 赵毅[1] 刘殿昌[1] 刘兵[1] 初同胜[1] 侯建玲[1] 郑荣涛[1] 

机构地区：[1]山东省皮肤病性病防治研究所,济南250022

出　　处：《中国麻风皮肤病杂志》2010年第5期303-306,共4页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测山东汉族梅毒患者与HLA-DRB1等位基因的相关性。方法:应用聚合酶链反应-序列特异性引物技术(PCR-SSP)对196例山东汉族梅毒患者与500例山东汉族正常对照的HLA-DRB1等位基因表现频率进行检测。结果:患者组DRB1*14等位基因的出现频率高于对照组(P<0.05);DRB1*16等位基因的出现频率与对照组无显著差异(P>0.05)。结论:HLA-DRB1*14等位基因可能是梅毒的易感基因。Objective： To associate the HLA - DRBI alleles with syphilis patients in Shandong Hart Nationality. Method： The allele frequency of HLA - DRB1 was detected in 196 syphilis patients and 500 healthy controls by polymerase chain reaction- sequence specific primers （PCR- SSP）. Results： The allele frequency of HLA- DRB1 14 was higher in syphilis patients when compared with the healthy controls （P 〈 0.05）. There was no significant difference in the frequency of HLA- DRB1 ＊ 16 between the two groups （ P 〉 0.05）. Conclusion： HLA- DRB1 14 may be a susceptible gene of syphilis.

关 键 词：梅毒 HLA等位基因 聚合酶链反应-序列特异性引物技术 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]