Wnt信号通路抑制因子DKK-1在骨质疏松发生中的研究进展  

Research progress on the role of Wnt signaling pathway inhibitor DKK-1 in the occurrence of osteoporosis

作　　者：罗磊[1] 谭钢[1] 康鹏德[1] 廉永运[1] 裴福兴[1] 

机构地区：[1]四川大学华西医院骨科,成都610041

出　　处：《中国骨质疏松杂志》2010年第5期365-368,共4页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(30872631)

摘　　要：Wnt信号通路对成骨细胞的发育及分化起着重要作用。近年来的研究发现,作为Wnt信号通路的抑制因子DKK-1能抑制骨形成,导致骨质疏松,而通过拮抗DKK-1的作用可使骨量增加。DKK-1可能成为治疗骨质疏松的新靶点。笔者对DKK-1在成骨细胞中的信号传导途径及其在骨质疏松中的作用做了综述。The Wnt signaling pathway plays a vital role in the process of osteoblast proliferation and differentiation. In recent years, a number of studies have found that this pathway can be impeded by an inhibitor,DKK-1. Over-expression of DKK-1 could affect bone formation and even lead to osteopenia. Blocking the DKK-1 as indicated by some researchers,could help to restore the function of osteoblast,and therefore increase bone mass. These findings suggest that using DKK-1 as a novel target could provide a new way for treating osteoporosis. Here,we reviewed the growing literature on the mechanism of DKK-1 inhibiting Wnt signaling transduction as well as its role in osteoporosis.

关 键 词：WNT信号通路 DKK-1 骨质疏松 

分 类 号：R318.04[医药卫生—生物医学工程]